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KCE reports vol. 6A Prenatale zorg 92
Study Ref Population Intervention Outcomes Results Comments Study
type
Guaschino et
al., 2003
Ugwumadu
et al. , 2003
Klebanoff et
al., 2004
67 112 women between 14 and 25
weeks of gestation with diagnosis
of asymptomatic BV
68 485 women between 12 and 22
weeks of gestation with diagnosis
of asymptomatic BV (Nugent´s
criteria)
69 1953 pregnant women with
asymptomatic bacterial vaginosis
on Gram stain
Antibiotic regimen (clindamycin
vaginal cream) vs.:
no treatment
Antibiotic regimen ( mean
gestation of 15.6 weeks) (oral
clindamycin) vs: placebo treatment
(double blind study)
At 16 to 23 weeks of gestation
women were assigned randomly:
658 women received two 2g doses
Preterm
delivery (< 37
weeks)
LBW ( <
2500g)
PROM
Preterm
delivery
Miscarriage
Mean gestation
at delivery
Admission to
NICU
Gram stain
score on one
occasion º 2
Preterm delivery, < 32
weeks (3 RCTs, n = 3080):
Peto OR 1.08, 95% CI 0.70
to 1.68
PPROM (3 RCTs, n = 3080):
Peto OR 0.32, 95% CI 0.59
to 1.17
Preterm delivery: 12.2% vs.
15.7% (p=0.78)
LBW: 6.1% vs. 13.7%
(p=0.32)
PROM: 14.5% vs. 5.9%
(p=0.19)
Preterm delivery: 5% vs 12%
(p