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KCE reports vol. 6A Prenatale zorg 91
Study Ref Population Intervention Outcomes Results Comments Stud
y
Gram staining (Spiegel´s
criteria):
LR + = 1.3 (95% CI 1.0 to
1.6)
LR - = 0.9 (95% CI 0.7 to
1.0)
Conclusion: Lack of difference in
the accuracy of the various tests
for predicting preterm birth in
both asymptomatic and
symptomatic women treatened
preterm labour
What are the antibiotic regimens of BV infection in pregnancy and how do they compare in terms of effectiveness and does screening for and
treating pregnant women found to have BV infection lead to improved maternal and perinatal outcomes?
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
McDonald et 4 [362] 10 RCTs, 4249 pregnant women Antibiotic regimen ( at 24 weeks) ÂTest-of-cureÊ Failure of test-of-cure (8
SR 1a
al., 2003
screened (or treated) for BV at 10 vs. placebo or no treatment
RCTs, n = 2835): Peto OR
to 26 weeks of gestation
Preterm
delivery
0.21, 95% CI 0.18 to 0.24
Preterm delivery, < 37
PPROM weeks (8 RCTs, n = 4062):
Peto OR 0.95, 95% CI 0.82
to 1.10
Preterm delivery, < 34
weeks (5 RCTs, n = 851):
Peto OR 1.20, 95% CI 0.69
to 2.07
type
EL