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KCE reports vol. 6A Prenatale zorg 90
Study Ref Population Intervention Outcomes Results
women 8/47 (16%) vs. BV
disappearance at second visit 7/45
(15.5%)
Comment
s
What is the accuracy of various tests for bacterial vaginosis in predicting preterm birth?
Study Ref Population Intervention Outcomes Results Comments Stud
y
Honest et
al., 2004
66 18 studies involving
17,868 pregnant
women
Meta-analysis to determine the
accuracy with which various
types of tests for bacterial
vaginosis predict spontaneous
preterm birth in pregnant
women
Estimates of likelihood ratios
for positive (LR+) and negative
(LR-) test results for the
various types of tests
Among asymptomatic women :
Clinical criteria:
LR+ = 0.98 (95% CI 0.59 to
1.6
LR- = 1.00 (95% CI 0.93 to
1.1)
Gram staining (Nugent´s
criteria):
LR + = 1.6 (95% CI 1.4 to
1.9)
LR - = 0.9 (95% CI 0.8 to
0.9)
Gram staining (Spiegel´s
citeria):
LR + = 2.4 (95% CI 1.4 to
4.9)
LR - = 0.81 (95% CI 0.64 to
1.0)
Among symptomatic women:
Unexplained
heterogenity
in the metaanalysis
of
accuracy
results
Study
type
type
EL
EL
SR 2 &
3