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KCE reports vol. 6A Prenatale zorg 89
Study Ref Population Intervention Outcomes Results Comments Study
type
(NugentÊs criteria) and gas-liquid
Gas-liquid chromatography:
chromatography (SpiegelÊs
criteria)
sensitivity 78%; specificity 81%
Is BV infection associated with adverse maternal and perinatal outcomes?
Study Ref Population Intervention Outcomes Results Comment
Flynn et al.,
1999
Gratacos
et al., 1998
4 [357] 8 case control
studies and 11
cohort studies
4 [358] 635 women
screened for BV in
Spain at < 35 weeks
Meta-analysis to determine
magnitude of risk associated
with BV (vs. no BV) and
preterm birth
Diagnosis based on Gramstained
smears based on
NugentÊs criteria
Positive women retested
within 4 to 8 weeks
Preterm birth (defined as < 35
weeks in two studies, < 36
weeks in one study, < 37 weeks
in all others)
BV diagnosis at initial visit
Preterm birth
OR (fixed) 1.85, 95% CI 1.62 to
2.11
OR (random) 2.05, 95% CI 1.67
to 2.50
RR (fixed, 10 cohort studies):
1.56, 95% CI 1.37 to 1.78
RR (random, 10 cohort studies):
1.75, 95% CI 1.34 to 2.29
125/635 (19.6%) with BV
Repeat sample taken in 92/125
(73.6%) of women
47/92 (51.1%) found still positive
for BV
Preterm birth: BV+ at initial visit
20/125 (16%) vs. BV at initial visit
26/510 (5%);
RR 3.1, 95%CI 1.8 to 5.4
Preterm birth in BV+ persistent
s
EL
Study EL
type
SR 2 &
3
CSS 3