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KCE reports vol. 6A Prenatale zorg 87
What are the outcomes associated with these antibiotic regimens?
Study Ref Population Intervention Outcomes Results Comments Study
Villar et
al.,
2001
4 [352] Cochrane systematic
review, updated 2000
8 RCTs comparing
different antibiotic
regimens
2 RCTs
2. b. Asymptomatic bacterial vaginosis
Single dose
compared with
4 to 7 day course
Gastrointestinal
side effects
Treatment group:
16/231 (6.9%)
Control group: 29/209
(14%)
Peto odds ratio: 0.53
(95% CI 0.31 to 0.91)
Results largely influenced by
a trial that was stopped mainly due to
side effects of sulphadimidine
What is the prevalence of asymptomatic BV infection in pregnancy?
Study Ref Population Intervention Outcomes Results Comment
Donders et al.,
1997
Goldenberg et
al., 1996
65 218 women attending
routine prenatal care in
Flanders (Belgium) during
the first trimester (ª 14
weeks) and with a living
singleton fetus
4 [355] 13,747 pregnant
women from 7 medical
centres in the USA from
1984 to 1989
Examination for microbiological flora by
microscopy of wet mount (n=89) or
PAP smear (n=130)
Assessment of BV either clinical
(Amsel), microscopic (clue cells) or by
culturing BV-associated bacteria
Women at 23 to 26 weeks
gestation were grouped according to
ethnic origin (white, black, Hispanic,
Asian-Pacific islander). BV was
diagnosed by Gram stain score º 7 in
conjunction with vaginal
pH > 4.5
Prevalence 27/218 (12.3%) Small
sample
size
Frequency
of BV
White women (n = 4049): 8.8%
Black women (n = 5285): 22.7%
(p < 0.05 compared with white
women)
Hispanic women (n = 4240):
15.9% (p < 0.05 compared with
white women)
s
EL
type
SR 1a
Study
type
EL
CSS 3
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