Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 86
Various countries Treatment group: 101/1044 (9.7%)
Control group: 127/879 (14.5%)
Peto odds ratio: 0.60 (95% CI 0.45
to 0.80)
Development of pyelonephritis:
Treatment group: 59/1125 (5.2%)
Control group: 203/1064 (19.1%)
Peto odds ratio: 0.24 (95% CI 0.19
to 0.32)
NNT: 7
to treatment allocation
Results were however
consistent from study to
study
None of the studies
collected adverse
outcomes of antibiotic
treatment
What antibiotic regimens are cost effective in treating asymptomatic bacteriuria in pregnant women?
Study Ref Population Intervention Outcomes Results Comments Study
Villar et
al.,
2001
4 [352] Cochrane systematic
review, updated 2000
8 RCTs comparing different
antibiotic regimens
Single dose
compared with
4 to 7 day course
2 RCTs
Preterm
delivery
Pyelonephritis
Preterm delivery:
Treatment group: 5/55 (9.1%)
Control group: 5/46 (10.9%)
Peto odds ratio: 0.81(95% CI 0.26
to 2.57)
Pyelonephritis:
Treatment group: 5/54 (9.3%)
Control group: 5/46 (2.1%)
Peto odds ratio: 3.09 (95% CI 0.54
to 17.55)
Only two RCTs reported
preterm birth rates and
pyelonephritis
EL
type
SR 1a