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KCE reports vol. 6A Prenatale zorg 84
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
patients over Bacteriuria > 1000 PPV
º 1 100. 66.6 16.2 100.0
7 years organisms/ml
NPV
0
McNair et 4 528 women at Urine culture Sensitivity Sensitivity: 100% (95% CI 88 to 100) Centrifugation with TES 3
al., 2000 [345] first antenatal compared with
Gram staining will
visit or centrifugation with Specificity Specificity: 7.7% (95% CI 5.6 to 10.5) potentially detect all
admission
cases of ASB but with a
with possible Gram stain
PPV
PPV: 7.3% (95% CI 5.3 to 10.1)
poor specificity will
preterm
incorrectly label over
labour
US hospital
NPV
NPV: 100% (95% CI 88.5 to 100)
90% of women as having
ASB
Bachman et
al., 1993
Shelton et
al., 2001
4
[347]
4
[343]
February 1998
to March
1999
1047 patients
attending
antenatal clinic
US hospital
200 women
with attending
antenatal clinic
20 identified
as having ASB
by urine
culture
US hospital
Urine culture
compared with Gram
staining
Urinary interleukin-8
vs. urine culture
Sensitivity
Specificity
Sensitivity
Specificity
PPV
NPV
Sensitivity 91.7%
Specificity 89.2%
Sensitivity: 70% ( 95% CI 46 to 88)
Specificity: 67 %( 95% CI 59 to 74)
PPV: 19% (95% CI 11 to 30)
NPV: 95% (95% CI 90 to 98)
Less than 10 % of cases
of ASB will potentially
be missed and a little
over 10% of cases
incorrectly labelled as
having ASB
Urinary interleukin-8
will potentially fail to
detect 30% of women
with asymptomatic
bacteriuria
TES 3
TES 3