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<strong>KCE</strong> reports vol. 6A Prenatale zorg 82 Study Ref Population Intervention Outcomes Results Comments Study type and James, [342] attending compared with 60.0 86.1 98.0 82.3 1993 antenatal clinic Specificity (SP) Leuc % % 16.1% % % UK hospital Reagent strip testing 67.5 99.7 98.5 98.2 (testing for individual PPV Nit % % 90.0% % % reagent strips then in 57.4 93.2 97.8 90.6 combination) NPV Pr % % 29.7% % % Leuc Leucocyte Accuracy Blood 57.4 % 93.2 % 29.7% 97.8 % 92.0 % Nit-Nitrite All 4 81.8 % 79.0 % 10.5% 99.3 % 73.6 % Bachman et al., 1993 Robertson et al., 1988 4 [347] 4 [346] 1047 patients attending antenatal clinic US hospital 750 patients attending an Army Medical Centre in the USA Pr-Protein Commercially available reagent strips used Urine culture compared with reagent strip testing (testing for nitrites) Commercially available reagent strips used Urine dipstickleucocyte esterase and nitrite compared with urine culture ASB defined as two Sensitivity Specificity PPV Sensitivity Specificity PPV 60.0 86.1 98.0 82.3 Leuc % % 16.1% % % 67.5 99.7 98.5 98.2 Nit % % 90.0% % % Either 73.0 85.9 98.9 83.0 + % % 15.9% % % Test S SP PPV Nitrite 45.8% 99.7% 78.6% LE 16.7% 97.2% 12.1% Both + Either + 12.5% 100% 100.0% 50.0% 96.9% 27.3% Test S SP NPV PPV Nitrite 43.4% 98.9 % LE 77.4% 96.1 % 95.1% 79.4% 97.9% 64.0% Reagent strip testing using nitrites only will potentially fail to detect 50% of cases of ASB Sensitivity of either test positive higher in this series than Shelton or 4[343] Bachman 4[347] EL TES 3 TES 3
<strong>KCE</strong> reports vol. 6A Prenatale zorg 83 Study Ref Population Intervention Outcomes Results Comments Study type EL clean catch 94.2 midstream urine Both + 32.2% % 99.2% 100.0% cultures showing at least 105 NPV cfu/ml of a single uropathogen Either + 92.0% 95.0 % 99.2% 62.6% McNair et 4 528 women at Urine culture Sensitivity Sensitivity: 80.6% (95% CI 63.4 to 91.2) TES 3 al., [345] first antenatal compared 2000 visit or with microscopic Specificity Specificity: 71.5% (95% CI 67.3 to 75.4) admission urinalysis with possible PPV PPV: 17.2% (95% CI 12.0 to 23.9) preterm Urinalysis positive if labour there was a count of 10 leucocytes/high- NPV NPV 98.1% (95% CI 95.8 to 99.1) US hospital power field Bachman et al., 1993 Abyad, 1991 4 [347] 4 [349] February 1998 to March 1999 1047 patients attending antenatal clinic US hospital Population taken from 3000 registered Urine culture compared with microscopic urinalysis Significant pyuria was inferred by the presence of more than 10 leucocytes/high- power field Urine culture compared with microscopic urinalysis Sensitivity Specificity Sensitivity Specificity Sensitivity 25% Specificity 99% WBC/HP S SP PPV NPV (%) F (%) (%) (%) >8 72.2 98.6 76.5 98.2 º5 94.4 95.3 56.7 99.6 Urinalysis will potentially fail to detect 75% of cases of ASB TES 3 TES 3
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NATIONALE RICHTLIJN PRENATALE ZORG:
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Nationale richtlijn prenatale zorg:
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KCE reports vol. 6A Prenatale zorg
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KCE reports 1. Effectiviteit en kos
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