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KCE reports vol. 6A Prenatale zorg 81
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
- Sensitivity: 45 (95% CI 23 to 68)
- Specificity: 62 (95% CI 55 to 69)
- PPV: 12 (95% CI 5 to 21)
- NPV: 91 (95% CI 85 to 95)
McNair et 4 528 women at Urine culture Sensitivity Sensitivity: 47.2% (95% CI 30.8 to 64.3)
TES 3
al., [345] first
compared with
2000
antenatal visit
or admission
reagent strip testing Specificity Specificity: 80.3% (95% CI 76.4 to 83.7)
with possible Reagent strip positive PPV
PPV: 14.9% (95% CI 9.2 to 23.1)
preterm if either nitrite or
labour
US hospital
leucocyte esterase
positive
Commercially
NPV
NPV: 95.9% (95% CI 92.8 to 97.1)
February 1998 available reagent
to March strips used
Tincello and
Richmond,
1998
4
[348]
1999
960 women
attending
antenatal
clinics
between June
and
September
1996
Commercial reagent
strip tests for the
presence of blood,
protein, nitrite and
leucocyte esterase vs.
microscopy and
culture of midstream
urine
Commercially
available reagent
strips used
Sensitivity
Specificity
PPV
NPV of reagent
strips in diagnosing
asymptomatic
bacteriuria
(defined as
1055colony forming units/ml
urine)
Etherington 4 898 women Urine culture Sensitivity (S)
Sensitivity: 33.3% (95% CI 26.5 to 40.1)
Specificity: 91.1% (95% CI 89.1 to 93.1)
PPV: 17.6% (95% CI 9.8 to 25.4)
NPV: 96.0 (95% CI 94.6 to 97.4)
RT S SP PPV NPV
Blinding of investigators
to
the different test results
is not indicated
TES 3
TES 3