Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 79
Study Ref Population Intervention Outcomes Results
antenatal visit: 16/500
(3.2%)
Bacteriuria at first
antenatal visit: 22/240
(9.2%); p value < 0.001
Comments Study
type
Mulla, 1960 4
[337]
Elder et al.,
1971
Gold et al.,
1966
4
[335]
4
[336]
100 patients with
bacteriuria
US hospital
Urine sample obtained
by catheter
Culture collected at 30th week of pregnancy
298 patients with
bacteriuria diagnosed by
a colony count of 105 organisms or more in 2
of 3 specimens of urine
US hospital
Samples taken at first
antenatal visit
Matched controls
65 patients with
bacteriuria
US hospital
50 patients with antibiotic
50 patients not given
medication until symptoms
appeared
Antibiotic used was
sulphadimethoxine
Bacteriuric patients:
Antibiotic 133
Placebo 148
Non bacteriuric patients:
Antibiotic 147
Placebo 132
Antibiotic: 6 weeks of
tetracycline
35 treated with
sulfadimethoxine till delivery
30 treated with placebo
Pyelonephritis Incidence of pyelonephritis:
Treatment group: 3/50 (6%)
Placebo group: 23/50 (46%)
Pyelonephritis Incidence of pyelonephritis:
Bacteriuric (placebo):
27/148 (18%)
Bacteriuric (antibiotic):
4/33 (12%)
Non-bacteriuric
(antibiotic): 3/146 (2.0%)
Non bacteriuric
(placebo): 3/132 (2.3%)
Prevalence of ASB
Prematurity
Pyelonephritis
Prevalence 65/1281 (5.1%)
Incidence of prematurity:
Bacteriuric (treated)
group: 2/65 (3.1%)
Method of
randomisation not
indicated
No losses to follow up
reported
Method analysis not
indicated
Randomisation was by
alternating with placebo
and would therefore be
predictable and with no
allocation concealment
Patients were
randomised according to
odd or even number
of allocation
EL
RCT 1b
CSNR 2a
QR 2a