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KCE reports vol. 6A Prenatale zorg 78
Study Ref Population Intervention Outcomes Results
(%)
Non-treatment group:
3/120 (2.5%)
Peto odds ratio (95% CI):
1.21 (0.24 to 6.13)
Comments Study
type
EL
Kincaid- 4 240 women with Antibiotic treatment vs. no Pyelonephritis Incidence of pyelonephritis: Method of
RCT 1b
Smith et al., [333] bacteriuria
treatment
Treated group: 4/133 randomisation not clear
1965
Prematurity
(3.0%)
500 women without Treatment continued till (excluding twin Placebo group: 41/128
bacteriuria
delivery
pregnancies and
pregnancies
(32;0%)
Bacteriuria defined as Antibiotic used was complicated by pre- Incidence of prematurity:
105 organisms/ml sulphmethoxydiazine at eclampsia)
Treated group:18/133
week 30 of pregnancy
(13.5%)
Confirmed on two
Pre-eclampsia
Placebo group: 25/129
counts
(19.4%); p value: NS
Australian hospital
Women attending
before 26 weeks of
gestation
Ampicillin or nitrofurantoin
was used if resistance was
demonstrated to any of the
above
Fetal loss
No bacteruria at first
antenatal visit: 13/500
(2.6%);
Bacteriuria at first
antenatal visit: 19/140
(7.9%); p value 0.001
Incidence of pre-eclampsia:
No bacteriuria at first
antenatal visit: 30/500
(6%)
Bacteriuria at first
antenatal visit: 26/240
(10.8%); p value: