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KCE reports vol. 6A Prenatale zorg 77
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Urine samples collected
by catheter and initial
bacteriuria defined as
colony counts of greater
than 105 - Initially negative culture Follow-up rate of > 90%
Antibiotics used were:
and long-term Rx [1/115
1. Sulfamethizole and
(0.9%)]
mandelamine combination
- Initially positive cultures
2 Nitofuradantoin
and drug Rx [3/69
of a single Mandelamine alone
(4.3%)]
organism/ml
3. Mandelamine alone
- Initially positive culture
and no long-term Rx
[8/41 (19.5%)]
Group [incidence of
prematurity]:
- Initially negative culture
(no Rx) [117/1003
(11.6%)]
- Initially negative culture
and long-term Rx
[16/138 (11.6%)]
- Initially positive cultures
and drug Rx [7/101
(6.9%)]
- Initially positive culture
and no long-term Rx
[6/27 (22.1%)]
Foley et 4 220 women with Treatment vs. non- Percentage of Percentage with sterile urine: Randomisation was by RCT 1b
al. ,1987 [331] asymptomatic
treatment of women with participants with Treatment group: 73% coin tossing
bacteriuria
confirmed bacteriuria; 100 sterile urine
Non-treatment: 48%
treated, 120 not treated
Allocation concealment
Hospital in Ireland
Incidence of Incidence of symptomaticUTi: method not indicated
symptomatic urinary ASB group: 2.3%
tract infections
Sterile urine group: 0.5% Follow-up rate 81%
Bacteriuria defined as
10 5 organisms per ml in
a single midstream
specimen of urine
Antibiotics used were
either sulphametizole or
nitrofurantoin
Incidence of
pyelonephritis
Incidence of pyelonephritis:
Treatment group: 3/100
Method of analysis not
indicated