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KCE reports vol. 6A Prenatale zorg 75
Study Ref Population Intervention Outcomes
Proportion of
Results
Caribbeans
Comments Study
type
EL
referrals in the 296/305 (97%) pregnancies with
first trimester fetuses diagnosed as homozygous
were terminated
Modell et 4 [276] 400 pregnancies in 138 Audit to evaluate the quality of Uptake of 80% uptake when offered among This study assumes CSS 3
al., 2000 women in the UK from antenatal screening for
prenatal British Pakistanis, 35/48 (73%) that antenatal
1990 to 1994 haemoglobinopathy and genetic diagnosis agreed to prenatal diagnosis in screening for Hb
counselling
first trimester, with 11/12 disorders is standard
affected pregnancies terminated,
compared with 11/28 (39%)
accepting prenatal diagnosis in the
second trimester, with 4/7
affected pregnancies terminated
practice in the UK
Ahmed 4 [184] 300 couples requesting Counselling and prenatal
Termination of 47/53 (89%) of affected
CSS 3
et al.,
prenatal diagnosis of diagnosis of beta-thalassaemia affected pregnancies were terminated
2000
beta-thalassaemia between 10 and 16 weeks (n = 15 pregnancies
during 3.5 years in diagnosed after 16th week)
6/53 terminations declined for
Pakistan
religious reasons
1. d. Blood grouping and red cell alloantibodies
No evidence tables available.
2. Screening for infections
2. a. Asymptomatic bacteriuria
What is the incidence of asymptomatic bacteriuria in pregnancy?
Study Ref Population Intervention Outcomes Results Comments Study
Foley et al., 1987 4 [331] 6883 women attending
antenatal clinics; hospital in
Treatment vs. non-treatment of
women with confirmed
Incidence of
asymptomatic
220/6883
(3.2%)
Randomisation by
coin-tossing
EL
type
RCT 1b