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KCE reports vol. 6A Prenatale zorg 73
Study Ref Population Intervention Outcomes Results
unaffected
pregnancies
Comments Study
type
Prevalence estimates:
17 infants born
each year with
beta-thalassaemia
(0.03/1000 live
births)
160 infants born
each year with
sickle cell disorder
(0.25/1000 live
births)
Does recording of racial background in the notes of pregnant women help in selective screening for haemoglobinopathies?
Study Ref Population Intervention Outcomes Results Comments Study
Aspinall
et al.,
2003
Modell et
al., 2000
4 [281] N/A Assessing effectiveness of
questions about ethnic origin
4 [276] 400 pregnancies in
138 women in the
UK from 1990 to
1994
Audit to evaluate the quality of
antenatal screening for
haemoglobinopathy and
genetic counselling
Quality of data
collected
Haemoglobinopath
y affected
Screening offered
Risk group misclassification as high as
20%
June quarter 2000 data from Hospital
Episode Statistics indicate ethnic
group data missing from 43% of
records in London and 37% in
England
138/400 (35%) pregnancies with
haemoglobinopathy
68/138 (49%) of affected pregnancies
had been offered screening at first
This study assumes
that antenatal
screening for Hb
disorders is standard
practice in the UK
EL
EL
type
RW 3
CSS 3