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KCE reports vol. 6A Prenatale zorg 71
Study Ref Population Intervention Outcomes Results Comments
0.41%
Study
type
Carriers for a 350 carriers for a
haemoglobin haemoglobin
variant variant (1.5%)
What are the adverse maternal and perinatal outcomes associated with haemoglobinopathies?
Study Ref Population Intervention Outcomes Results Comments Study
Davies
et al.,
2000
4 [275] 751 pregnant women with
sickle trait or disease and
265 pregnant women with
beta-thalassaemia trait or
disease from 1986 to 1995
Women attended counselling (n = 623/751
(83%) in sickle cases; n = 246/265 (93%) in
beta-thalassaemia cases), partners tested (n
= 481/623 (77%) in sickle cases; n = 234/246
(88%) in beta-thalassaemia cases), postnatal
diagnosis offered
Pregnancies at
risk
Outcomes of
pregnancies at
risk
Estimates of
prevalence among
all live births in
England
Sickle cell pregnancies
at risk: 113/481 (23%)
Beta-thalassaemia
pregnancies at risk:
22/234 (9.4%)
Outcomes of at risk
pregnancies:
Sickle cell:
16 of 108 women
who returned for
follow-up accepted
prenatal diagnosis
(15%)
3 terminations
from 4 affected
pregnancies
22 affected births
from 92 of 108
women who did
The prevalence
estimates allow
for terminations
type
HTA
RW
CSS
EL
EL
3