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KCE reports vol. 6A Prenatale zorg 70
Study Ref Population Intervention Outcomes Results
RCT, n = 48): Peto OR 7.72 (95%
CI 0.47 to 127.14)
Comments Study
type
What are the side effects of iron supplementation in pregnancy and how can they be minimised?
Study Ref Population Intervention Outcomes Results Comments Study
Cuervo and
Mohammed,
2001
4 [274] 5 RCTs, 1234
pregnant
women with
anaemia (Hb < 11
g/dl) in pregnancy
1. b. Platelets and leukocytes
No evidence tables available.
1. c. Haemoglobinopathies
14 variations of
interventions for anaemia, including
all types of iron preparations (oral,
slow
release, intramuscular and
intravenous iron, blood transfusions,
and recombinant erythropoietin)
Women with
anaemia
Maternal
morbidity and
mortality
Neonatal
morbidity and
mortality
Oral iron vs. placebo: anaemia (1
RCT, n = 125) Peto OR 0.12
(95% CI 0.06 to 0.24); no
published data on clinically
relevant outcomes
All trials were
assessed to be
of poor quality
What is the prevalence of haemoglobinopathies in Belgium?
Study Ref Population Intervention Outcomes Results Comments Study
Gulbis et
al., 1999
64 23,136 cord blood samples were
obtained in 8 hospital nurseries in
Brussels between December 1994
and June 1998.
Screening for
haemoglobinopathies by
isoelectric focussing
Cases of sickle
cell disease
Cases of beta
thalassemia
major
11 cases of sickle
cell disease
(0.048%)
1 case of beta
thalassemia major
45% of the newborns were
from regions at risk for
haemoglobinopathies
In Belgium: estimated
prevalence of
haemoglobinopathy carriers is
EL
EL
type
SR 1a
EL
type
CSS 3