Publikationen - University of Bonn - Medical Center (IMBIE)

Publikationen
14.01.2013
In press
Originalarbeiten: Erst- und Letztautorenschaften
1. Dodel R, Rominger A, Bartenstein P, Barkhof F, Blennow K, Förster S, Winter Y, Bach JP,
Popp J, Alferink J, Wiltfang J, Buerger K, Otto M, Antuono P, Jacoby M, Richter R, Stevens J,
Melamed I, Goldstein J, Haag S, Wietek S, Farlow M, Jessen F. Intravenous immunoglobulins
for the treatment of mild to moderate Alzheimer’s disease: a phase II, randomised, doubleblind,
placebo-controlled dose-finding trial. Lancet Neurol. In press IF: 23.462
2. Jessen F, Wolfsgruber S, Wiese B, Bickel H, Mösch E, Kaduszkiewicz H, Pentzek M, Riedel-
Heller SG, Luck T, Fuchs A, Weyerer S, Werle J, van den Bussche, Scherer M, Maier W,
Wagner M, for the AgeCoDe study group. AD dementia risk in late MCI, in early MCI and in
subjective memory impairment. Alzheimers Dement. In press. IF: 6.373
2013
Originalarbeiten: Koautorenschaften
1. Popp J, Meichsner S, Kölsch H, Lewczuk P, Maier W, Kornhuber J, Jessen F, Lütjohann D.
2013. Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's
Disease. Biochem Pharmacol. Online. IF 4.705
2012
Originalarbeiten: Erst- und Letztautorenschaften
1. Scheef L, Spottke A, Daerr M, Joe A, Striepens N, Kölsch H, Popp J, Daamen M, Gorris D,
Heneka MT, Boecker H,. Heneka MT, Boecker H, Biersack HJ, Maier W, Schild HH, Wagner
M, Jessen F. Glucose metabolism, gray matter structure and memory decline in subjective
memory impairment. Neurology. 79:1332-1339. 2012. IF: 8.312

Professor Dr. med. Frank Olaf Jessen
2. Lewczuk P, Popp J, Lelental N, Kölsch H, Maier W, Kornhuber J, Jessen F. Cerebrospinal fluid
soluble amyloid-β protein precursor as a potential novelbiomarkers of Alzheimer's disease. J
Alzheimers Dis. 28:119-125. 2012. IF: 3.745
Originalarbeiten: Koautorenschaften
1. Besong-Agbo D, Wolf E, Jessen F, Oechsner M, Hametner E, Poewe W, Reindl M, Oertel WH,
Noelker C, Bacher M, Dodel R. Naturally occurring α-synuclein autoantibody levels are lower in
patients with Parkinson disease. Neurology. Online. 2012. IF: 8.312
2. Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R,
Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, Thomas
C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, BrayneC, Rubinsztein
DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B,
Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox
N, Rossor M, Collinge J, Maier W, Jessen F, Kölsch H, Heun R, Schürmann B, van den
Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M,
Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G,
Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Davies G, Harris SE, Starr JM, Deary
IJ, Al-Chalabi A, ShawCE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM,
Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG,
Jones L, Holmans PA, O'Donovan MC, Owen MJ, Williams J. The role of variation at AβPP,
PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis. 28:377-387.
2012. IF: 3.745
3. Kummer M, Vogl T, Axt D, Griep A, Viera-Saecker A, Jessen F, Gelpi E, Roth J, Heneka M.
Mrp14 deficiency ameliorates Aß03B2; burden by increasing microglial phagocytosis and
modulation of APP processing. J Neurosci. 32:17824-17829. 2012. IF: 7.115
4. Semmler A, Widmann CN, Okulla T, Urbach H, Kaiser M, Widman G, Mormann F, Weide J,
Fliessbach K, Hoeft A, Jessen F, Putensen C, Heneka MT. Persistent cognitive impairment,
hippocampal atrophy and EEG changes in sepsis survivors. J Neurol Neurosurg Psychiatry.
Online. 2012. IF: 4.764
5. van der Zee J, Gijselinck I, Dillen L, Van Langenhove T, Theuns J, Engelborghs S, Philtjens S,
Vandenbulcke M, Sleegers K, Sieben A, Bäumer V, Maes G, Corsmit E, Borroni B, Padovani
A, Archetti S, Perneczky R, Diehl-Schmid J, de Mendonça A, Miltenberger-Miltenyi G, Pereira
S, Pimentel J, Nacmias B, Bagnoli S, Sorbi S, Graff C, Chiang HH, Westerlund M, Sanchez-
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Professor Dr. med. Frank Olaf Jessen
Valle R, Llado A, Gelpi E, Santana I, Almeida MR, Santiago B, Frisoni G, Zanetti O, Bonvicini
C, Synofzik M, Maetzler W, Vom Hagen JM, Schöls L, Heneka MT, Jessen F, Matej R,
Parobkova E, Kovacs GG, Ströbel T, Sarafov S, Tournev I, Jordanova A, Danek A, Arzberger
T, Fabrizi GM, Testi S, Salmon E, Santens P, Martin JJ, Cras P, Vandenberghe R, De Deyn
PP, Cruts M, Van Broeckhoven C; on behalf of the European Early-Onset Dementia (EOD)
Consortium. A Pan-European study of the C9orf72 Repeat Associated with FTLD: Geographic
Prevalence, Genomic Instability and Intermediate Repeats. Hum Mutat. Online. 2012. IF: 5.686
6. Smith DE, Smulders YM, Blom HJ, Popp J, Jessen F, Semmler A, Farkas M, Linnebank M.
Determinants of the essential one-carbon metabolism metabolites, homocysteine, Sadenosylmethionine,
S-adenosylhomocysteine and folate, in cerebrospinal fluid. Clin Chem
Lab Med. 50:1641-1647. 2012. IF: 2.150
7. Popp J, Lewczuk P, Kölsch H, Meichsner S, Maier W, Kornhuber J, Jessen F, Lütjohann D.
Cholesterol metabolism is associated with soluble amyloid precursor protein production in
Alzheimer's disease. J Neurochem. 123:310-316. 2012. IF: 4.061
8. Luppa M, Riedel-Heller SG, Stein J, Leicht H, König HH, van den Bussche H, Maier W,
Scherer M, Bickel H, Mösch E, Werle J, Pentzek M, Fuchs A, Eisele M, Jessen F, Tebarth F,
Wiese B, Weyerer S; AgeCoDe study group. Predictors of institutionalisation in incident
dementia--results of the German Study on Ageing, Cognition and Dementia in Primary Care
Patients (AgeCoDe study). Dement Geriatr Cogn Disord. 33:282-288. 2012. IF: 2.141
9. Arlt S, Schwedhelm E, Kölsch H, Jahn H, Linnebank M, Smulders Y, Jessen F, Böger RH,
Popp J. Dimethylarginines, Homocysteine Metabolism, and Cerebrospinal Fluid Markers for
Alzheimer's Disease. J Alzheimers Dis. 31:751-758. 2012. IF: 3.745
10. Luck T, Luppa M, Wiese B, Maier W, van den Bussche H, Eisele M, Jessen F, Weeg D,
Weyerer S, Pentzek M, Leicht H, Koehler M, Tebarth F, Olbrich J, Eifflaender-Gorfer S, Fuchs
A, Koenig HH, Riedel-Heller SG; for the AgeCoDe Study Group. Prediction of Incident
Dementia: Impact of Impairment in Instrumental Activities of Daily Living and Mild Cognitive
Impairment – Results From the German Study on Ageing, Cognition, and Dementia in Primary
Care Patients. Am J Geriatr Psychiatry. Online. 2012. IF: 3.638
11. Köhler M, Kliegel M, Kaduszkiewicz H, Bachmann C, Wiese B, Bickel H, Mösch E, Weyerer S,
Werle J, Fuchs A, Pentzek M, Leicht H, König HH, Luppa M, Riedel-Heller S, Jessen F, Maier
W, Scherer M, Wagner M; for the Ageing, Cognition and Dementia in Primary Care Patients
(AgeCoDe) study group. Effect of Cardiovascular and Metabolic Disease on Cognitive Test
Performance and Cognitive Change in Older Adults. J Am Geriatr Soc. Online. 2012. IF: 3.737
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Professor Dr. med. Frank Olaf Jessen
12. Schuhmacher A, Mössner R, Jessen F, Scheef L, Block W, Belloche AC, Lennertz L, Welper
H, Höfels S, Pfeiffer U, Wagner M, Maier W, Schwab S, Zobel A. Association of amygdala
volumes with cortisol secretion in unipolar depressed patients. Psychiatry Res. Online. 2012.
IF: 2.964
13. Peters O, Lorenz D, Fesche A, Schmidtke K, Hüll M, Perneczky R, Rüther E, Möller HJ,
Jessen F, Maier W, Kornhuber J, Jahn H, Luckhaus C, Gertz HJ, SchröderJ, Pantel J, Teipel
S, Wellek S, Frölich L, Heuser I. A Combination of Galantamine and Memantine Modifies
Cognitive Function in Subjects with Amnestic MCI. J Nutr Health Aging. 16:544-548. 2012. IF:
2.686
14. Zimmermann T, Kaduszkiewicz H, vd Bussche H, Schön G, Wegscheider K, Werle J, Weyerer
S, Wiese B, Olbrich J, Weeg D, Riedel-Heller S, Luppa M, Jessen F, Abholz HH, Maier W,
Pentzek M. Reliabilität ärztlicher Morbiditätsangaben zu chronischen Krankheiten.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 55:260-269. 2012. IF:
0.658
15. Wagner M, Wolf S, Reischies FM, Daerr M, Wolfsgruber S, Jessen F, Popp J, Maier W, Hüll
M, Frölich L, Hampel H, Perneczky R, Peters O, Jahn H, Luckhaus C, Gertz HJ, Schröder J,
Pantel J, Lewczuk P, Kornhuber J, Wiltfang J. Biomarker validation of a cued recall memory
deficit in prodromal Alzheimer disease. Neurology. 78:379-386. 2012. IF: 8.312
16. Schrijvers EM, Schürmann B, Koudstaal PJ, van den Bussche H, Van Duijn CM, Hentschel F,
Heun R, Hofman A, Jessen F, Kölsch H, Kornhuber J, Peters O, Rivadeneira F, Rüther E,
Uitterlinden AG, Riedel-Heller S, Dichgans M, WiltfangJ, Maier W, Breteler MM, Ikram MA.
Genome-wide association study of vascular dementia. Stroke. 43:315-319. 2012. IF: 5.729
Originalarbeiten: Mitglied in Autorengruppen
1. Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, Stretton A, Jones N,
Gerrish A, Chapman J, Ivanov D, Moskvina V, Lovestone S, Priotsi P, Lupton M, Brayne C, Gill
M, Lawlor B, Lynch A, Craig D, McGuinness B, Johnston J, Holmes C, Livingston G, Bass NJ,
Gurling H, McQuillin A; the GERAD Consortium; the National Institute on Aging Late-Onset
Alzheimer's Disease Family Study Group, Holmans P, Jones L, Devlin B, Klei L, Barmada MM,
Demirci FY, Dekosky ST, Lopez OL, Passmore P, Owen MJ, O'Donovan MC, Mayeux R,
Kamboh MI, Williams J. Genome-wide association study of Alzheimer's disease with psychotic
symptoms. Mol Psychiatry. 17:1316-1327. 2012. IF: 13.668
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Professor Dr. med. Frank Olaf Jessen
2. Chapman J, Rees E, Harold D, Ivanov D, Gerrish A, Sims R, Hollingworth P, Stretton A,
GERAD1 Consortium, Holmans P, Owen MJ, O’Donovan MC, Williams J, Kirov G. A genomewide
study shows a limited contribution of rare copy number variants to Alzheimer’s disease
risk. Hum Mol Genet. Online. 2012. IF: 7.636
3. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C,
Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC,
Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A,
Hardy J; the Alzheimer Genetic Analysis Group. TREM2 Variants in Alzheimer's Disease. N
Engl J Med. Online. 2012. IF: 53.298
4. Hamilton G, Harris SE, Davies G, Liewald DC, Tenesa A, Payton A, Horan MA, Ollier WE,
Pendleton N; Genetic and Environmental Risk for Alzheimer's Disease (GERAD1)
Consortium, Starr JM, Porteous D, Deary IJ. The role of ECE1 variants in cognitive ability in
old age and Alzheimer's disease risk. Am J Med Genet B Neuropsychiatr Genet. 159B:696-
709. 2012. IF: 3.705
5. Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J,
Lovestone S, Goate A, Younkin S, Passmore P; Genetic and Environmental Risk for
Alzheimer's Disease Consortium, Morgan K; Alzheimer's Research UK Consortium. Genetic
variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide
association studies (GWAS). Neurobiol Aging. 33:1849.e5-18. 2012. IF: 6.189
6. Hudson G, Sims R, Harold D, Chapman J, Hollingworth P, Gerrish A, Russo G, Hamshere M,
Moskvina V, Jones N, Thomas C, Stretton A, Holmans PA, O'Donovan MC, Owen MJ, Williams
J, Chinnery PF; GERAD1 Consortium. No consistent evidence for association between
mtDNA variants and Alzheimer disease. Neurology. 78:1038-1042. 2012. IF: 8.312
7. Eisele M, Zimmermann T, Köhler M, Wiese B, Heser K, Tebarth F, Weeg D, Olbrich J, Pentzek
M, Fuchs A, Weyerer S, Werle J, Leicht H, König HH, Luppa M, Riedel-Heller S, Maier W,
Scherer M; AgeCoDe Study Group. Influence of social support on cognitive change and
mortality in old age: results from the prospective multicentre cohort study AgeCoDe. BMC
Geriatr. 12:9. 2012. kein IF
8. Stein J, Luppa M, Maier W, Tebarth F, Heser K, Scherer M, Zimmermann T, Eisele M, Bickel
H, Mösch E, Weyerer S, Werle J, Pentzek M, Fuchs A, Wiese B, Prokein J, König HH, Leicht
H, Riedel-Heller SG; AgeCoDe Study Group. The assessment of changes in cognitive
functioning in the elderly: age- and education-specific reliable change indices for the SIDAM.
Dement Geriatr Cogn Disord. 33:73-83. 2012. IF: 2.141
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Professor Dr. med. Frank Olaf Jessen
9. Hamilton G, Killick R; Genetic and Environmental Risk for Alzheimer's Disease
Consortium; Translational Genomics Research Institute Consortium, Lambert JC, Amouyel P;
European Alzheimer Disease Initiative, Carrasquillo MM, Pankratz VS, Graff-Radford NR,
Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R. Functional and genetic
analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiol Aging.
33:1848.e1-13. 2012. IF: 6.189
10. Stein J, Luppa M, Maier W, Wagner M, Wolfsgruber S, Scherer M, Köhler M, Eisele M,
Weyerer S, Werle J, Bickel H, Mösch E, Wiese B, Prokein J, Pentzek M, Fuchs A, Leicht H,
König HH, Riedel-Heller SG; AgeCoDe Study Group (Mitglied der Autorengruppe).
Assessing cognitive changes in the elderly: reliable change indices for the Mini-Mental State
Examination. Acta Psychiatr Scand. 126:208-218. 2012. IF: 4.220
11. Forstmeier S, Maercker A, Maier W, van den Bussche H, Riedel-Heller S, Kaduszkiewicz H,
Pentzek M, Weyerer S, Bickel H, Tebarth F, Luppa M, Wollny A, Wiese B, Wagner M;
AgeCoDe Study Group. Motivational reserve: motivation-related occupational abilities and risk
of mild cognitive impairment and Alzheimer disease. Psychol Aging. 27:353-363. 2012. IF:
2.729
12. Luppa M, Riedel-Heller SG, Luck T, Wiese B, van den Bussche H, Haller F, Sauder M, Mösch
E, Pentzek M, Wollny A, Eisele M, Zimmermann T, König HH, Maier W, Bickel H, Werle J,
Weyerer S; AgeCoDe study group. Age-related predictors of institutionalization: results of the
German study on ageing, cognition and dementia in primary care patients (AgeCoDe). Soc
Psychiatry Psychiatr Epidemiol. 47:263-270. 2012. IF: 2.696
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F. Alzheimer Demenz. Nicht medikamentöse Therapie im Fokus. Info Neurologie &
Psychiatrie. 6:50-54. 2012.
2. Haupt M, Adler G, Bohlken J, Reischies FM, Eckert A, Walbert H, Jessen F. Subjektive
Gedächtnisstörung: Ein Aufruf zum aktiven Management älterer Patienten, die in der ärztlichen
Praxis über nachlassende Gedächtnisleistung klagen. Neurotransmitter. 23, Beilage „Medizin
Forum“:1-8. 2012.
3. Jessen F. Therapie der Demenz: State of the Art Demenzerkrankungen. Exzellenzforschung in
der Medizin. 2:60-65. 2012.
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Professor Dr. med. Frank Olaf Jessen
2011
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Fingerhut N, Sprinkart AM, Kühn KU, Petrovsky N, Maier W, Schild HH, Block W,
Wagner M, Träber F. N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in
Patients With Schizophrenia. Schizophr Bull. Online. 2011. IF: 8.800
2. Jessen F, Lewczuk P, Gür O, Block W, Ende G, Frölich L, Hammen T, Arlt S, Kornhuber J,
Kucinski T, Popp J, Peters O, Maier W, Träber F, Wiltfang J. Association of N-acetylaspartate
and cerebrospinal fluid Aβ42 in dementia. J Alzheimers Dis. 27:393-399. 2011. IF: 3.745
3. Erk S, Spottke A, Meisen A, Wagner M, Walter H, Jessen F. Evidence of neuronal
compensation during episodic memory in subjective memory impairment. Arch Gen Psychiatry.
68:845-852. 2011. IF: 12.016
4. Schürmann B, Wiese B, Bickel H, Weyerer S, Riedel-Heller SG, Pentzek M, Bachmann C,
Williams J, van den Bussche H, Maier W, Jessen F. Association of the Alzheimer's disease
clusterin risk allele with plasma clusterin concentration. J Alzheimers Dis. 25:421-424. 2011. IF:
3.745
5. Jessen F, Wiese B, Bickel H, Eiffländer-Gorfer S, Fuchs A, Kaduszkiewicz H, Köhler M, Luck
T, Mösch E, Pentzek M, Riedel-Heller SG, Wagner M, Weyerer S, Maier W, van den Bussche
H; AgeCoDe Study Group. Prediction of dementia inprimary care patients. PLoS One.
6:e16852. 2011. IF: 4.092
6. Striepens N, Scheef L, Wind A, Meiberth D, Popp J. Spottke A, Kölsch H, Wagner M, Jessen
F. Interaction effects of subjective memory impairment and ApoE4 genotype On episodic
memory and hippocampal volume. Psychol Med. 41:1977-2006. 2011. IF: 6.159
Originalarbeiten: Koautorenschaften
1. Papassotiropoulos A, Henke K, Stefanova E, Aerni A, Müller A, Demougin, P, Vogler C,
Sigmund JC, Gschwind L, Huynh KD, Coluccia D, Mandodori CR, Hänggi J, Buchmann A,
Kostic V, Novakovic I, van den Bussche H, Kaduszkiewicz H, Weyerer S, Bickel H, Riedel-
Heller S, Pentzek M, Wiese B, Dichgans M, Wagner M, Jessen F, Maier W, de Quervain DJF.
A genome-wide survey of human short-term memory. Mol Psychiatry. 16:184-192. 2011. IF:
13.668
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Professor Dr. med. Frank Olaf Jessen
2. Teipel SJ, Reuter S, Stieltjes B, Acosta-Cabronero J, Ernemann U, FellgiebelA, Filippi M,
Frisoni G, Hentschel F, Jessen F, Klöppel S, Meindl T, Pouwels PJ, Hauenstein KH, Hampel
H. Multicenter stability of diffusion tensor imagingmeasures: a European clinical and physical
phantom study. Psychiatry Res. 194:363-371. 2011. IF: 2.964
3. Voigt-Radloff S, Graff M, Leonhart R, Schornstein K, Jessen F, Bohlken J, MetzB, Fellgiebel A,
Dodel R, Eschweiler G, Vernooij-Dassen M, Olde Rikkert M, Hüll M. A multicentre RCT on
community occupational therapy in Alzheimer's disease: 10sessions are not better than one
consultation. BMJ Open. 1:e000096. 2011. kein IF
4. Teipel SJ, Peters O, Heuser I, Jessen F, Maier W, Froelich L, Arlt S, Hüll M, Gertz HJ,
Kornhuber J, Wiltfang J, Thome J, Rienhoff O, Meindl T, Hampel H, Grothe M. Atrophy
outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and
analysis approaches on sample sizes. World J Biol Psychiatry. 12 Suppl 1:109-113. 2011. IF:
2.385
5. Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape
HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT. Nitration of tyrosine
10 critically enhances amyloid β aggregation and plaque formation. Neuron. 71:833-844. 2011.
IF: 14.736
6. Reese JP, Hessmann P, Seeberg G, Henkel D, Hirzmann P, Rieke J, Baum E, Dannhoff F,
Müller MJ, Jessen F, Geldsetzer MB, Dodel R. Cost and care of patients with Alzheimer's
disease: clinical predictors in German health care settings. J Alzheimers Dis. 27:723-736.
2011. IF: 3.745
7. Schipke CG, Jessen F, Teipel S, Luckhaus C, Wiltfang J, Esselmann H, Frölich L, Maier W,
Rüther E, Heppner FL, Prokop S, Heuser I, Peters O. Long-term stability of Alzheimer's
disease biomarker proteins in cerebrospinal fluid. J Alzheimers Dis. 26:255-262. 2011. IF:
3.745
8. Frings L, Klöppel S, Teipel S, Peters O, Frölich L, Pantel J, Schröder J, Gertz HJ, Arlt S,
Heuser I, Kornhuber J, Wiltfang J, Maier W, Jessen F, Hampel H, Hüll M. Left anterior
temporal lobe sustains naming in Alzheimer's dementia and mild cognitive impairment. Curr
Alzheimer Res. 8:893-901. 2011. IF: 3.953
9. Vanmierlo T, Popp J, Kölsch H, Friedrichs S, Jessen F, Stoffel-Wagner B, Bertsch T,
Hartmann T, Maier W, von Bergmann K, Steinbusch H, Mulder M, Lütjohann D. The plant
sterol brassicasterol as additional CSF biomarker in Alzheimer's disease. Acta Psychiatr
Scand. 24:184-192. 2011. IF: 4.220
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Professor Dr. med. Frank Olaf Jessen
10. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R,
Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards
A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne
C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness
B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe
PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen
F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J,
Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate
AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K,
Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin
A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R,
Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS,
Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen
RC; Alzheimer's Disease Neuroimaging Initiative, van Duijn CM, Breteler MM, Ikram MA,
DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S; CHARGE consortium, Berr C,
Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M; EADI1
consortium, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M,
Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S,
Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D,
Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E,
Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù
P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A,
Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K,
Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J. Common variants at ABCA7,
MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat
Genet. 43:429-435. 2011. IF: 35.532
Originalarbeiten: Mitglied in Autorengruppen
1. Leicht H, Heinrich S, Heider D, Bachmann C, Bickel H, van den Bussche H, Fuchs A, Luppa M,
Maier W, Mösch E, Pentzek M, Rieder-Heller SG, Tebarth F, Werle J, Weyerer S, Wiese B,
Zimmermann T, König HH; AgeCoDe study group. Net costs of dementia by disease stage.
Acta Psychiatr Scand. 124:384-395. 2011. IF: 4.220
2. Weyerer S, Schäufele M, Wiese B, Maier W, Tebarth F, van den Bussche H, Pentzek M, Bickel
H, Luppa M, Riedel-Heller SG; German AgeCoDe Study group (German Study on Ageing,
Cognition and Dementia in Primary Care Patients). Current alcohol consumption and its
9

Professor Dr. med. Frank Olaf Jessen
relationship to incident dementia: results from a 3-year follow-up study among primary care
attenders aged 75 years and older. Age Ageing. 40:456-463. 2011. IF: 3.090
3. Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK,
Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, Riemenschneider M, Owen M,
Harold D, Hollingworth P, Cellini E, Sorbi S, Nacmias B, Takeda M, Pericak-Vance MA, Haines
JL, Younkin S, Williams J, van Broeckhoven C, Farrer LA, St George-Hyslop PH, Mayeux R;
Genetic and Environmental Risk in Alzheimer Disease 1 Consortium. Meta-analysis of the
association between variants in SORL1 and Alzheimer disease. Arch Neurol. 68:99-106. 2011.
IF: 7.584
4. Koehler M, Kliegel M, Wiese B, Bickel H, Kaduszkiewicz H, van den Bussche H, Eifflaender-
Gorfer S, Eisele M, Fuchs A, Koenig HH, Leicht H, Luck T, Maier W, Moesch E, Riedel-Heller
S, Tebarth F, Wagner M, Weyerer S, Zimmermann T, Pentzek M; AgeCoDe study group.
Malperformance in verbal fluency and delayed recall as cognitive risk factors for impairment in
instrumental activities of daily living. Dement Geriatr Cogn Disord. 31:81-88. 2011. IF: 2.141
Übersichtsarbeiten
1. Hampel H, Prvulovic D, Teipel S, Jessen F, Luckhaus C, Frölich L, Riepe MW, Dodel R, Leyhe
T, Bertram L, Hoffmann W, Faltraco F; German Task Force on Alzheimer's Disease (GTF-AD).
The future of Alzheimer's disease: the next 10 years. Prog Neurobiol. 95:718-728. 2011. IF:
8.874
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F. Diagnostischer Nihilismus ist nicht angesagt. Ärztliches Journal Reise & Medizin /
Neurologie/Psychiatrie. 12:28-30. 2011.
2. Jessen F. Therapie der Demenz. Psychiatrie und Psychotherapie up2date. 3: 141-147. 2011.
3. Jessen F. Diagnostik der Demenz. Psychiatrie und Psychotherapie up2date. 1:9-15. 2011.
Buchbeiträge
10

Professor Dr. med. Frank Olaf Jessen
1. Maier W, Jessen F. Prospective studies: Aids to establish early and accurate dementia
diagnoses. In: Versorgungsforschung für demenziell erkrankte Menschen, Eds. Dibelius O,
Maier W. Kohlhammer GmbH Stuttgart. 18-23. 2011. ISBN: 978-3-17-021331-9
2010
Originalarbeiten: Erst- und Letztautorenschaften
1. Popp J, Lewczuk P, Frommann I, Kölsch H, Kornhuber J, Maier W, Jessen F. Cerebrospinal
fluid markers for Alzheimer's disease over the lifespan: effects ofage and the APOEε4
genotype. J Alzheimers Dis. 22:459-468. 2010. IF: 3.745
2. Jessen F, Kaduszkiewicz H, Daerr M, Bickel H, Pentzek M, Riedel-Heller S, Wagner M,
Weyerer S, Wiese B, van den Bussche H, Broich K, Maier W. Anticholinergic drug use and risk
for dementia: target for dementia prevention. Eur Arch Psychiatry Clin Neurosci. 260 Suppl
2:S111-115. 2010. IF: 3.494
3. Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G,
Blom H, Stoffel-Wagner B, Kölsch H, Weller M, Jessen F. S-adenosylmethionine is decreased
in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 7:373-378.
2010. IF: 3.056
4. Scheef L, Manka C, Daamen M, Kühn KU, Maier W, Schild HH, Jessen F. Resting state
perfusion in unmedicated schizophrenic patients-A CASL study at 3.0T. Radiology. 256:253-
260. 2010. IF: 5.726
5. Jessen F, Wiese B, Bachmann C, Eifflaender-Gorfer S, Haller F, Kölsch H, Luck T, Mösch E,
Kaduszkiewicz H, Wagner M, Wollny A, Pentzek M, Riedel-Heller SG, Weyerer S, van den
Bussche H, Maier W, Bickel H. Prediction of dementia by subjective memory impairment –
effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry.
67:414-422. 2010. IF: 12.016
6. Striepens N, Scheef l L, Wind A, Popp J, Spottke A, Suliman H, Wagner M, Schild HH, Jessen
F. Volume loss of the medial temporal lobe structures in subjective memory impairment.
Dement Geriatr Cogn Disord. 29:75-81. 2010. IF: 2.141
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Professor Dr. med. Frank Olaf Jessen
Originalarbeiten: Koautorenschaften
1. Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, PocklingtonA,
Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR,
Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B,
Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C,
Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W,
Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O,
Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM,
Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H,
McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R,
Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E,
Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J.
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of
Alzheimer's disease. PLoS One. 5:e13950. 2010. IF: 4.092
2. Kaduszkiewicz H, Zimmermann T, van den Bussche H, Bachmann C, Wiese B, Bickel H,
Mösch E, Romberg HP, Jessen F, Cvetanovska-Pllashniku G, Maier W, Riedel-Heller SG,
Luppa M, Sandholzer H, Weyerer S, Mayer M, Hofmann A, Fuchs A, Abholz HH, Pentzek M fot
the AgeCoDe study group. Do general practioners recognize mild cognitive impairment in their
patients? J Nutr Health Aging. 14:697-702. 2010. IF: 2.686
3. Teipel SJ, Ewers M, Wolf S, Jessen F, Kölsch H, Arlt S, Luckhaus C, Schönknecht P,
Schmidtke K, Heuser I, Frölich L, Ende G, Pantel J, Wiltfang J, Rakebrandt F, Peters O, Born
C, Kornhuber J, Hampel H. Multicentre variability of MRI-based medial temporal lobe volumetry
in Alzheimer's disease. Psychiatry Res. 182:244-250. 2010. IF: 2.964
4. Webster J, Reiman EM, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ,
Craig DW, Coon KD, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem
M, Mastroeni D, Grover A, Rogers J, Heun R, Jessen F, Kölsch H, Heward CB, Ravid R,
Hutton ML, Melquist S, Petersen RC, Caselli RJ, Papassotiropoulos A, Stephan DA, Hardy J,
Myers A. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's
disease and fails to replicate most candidates from Meta-analysis. Int J Mol Epidemiol Genet.
1:19-30. 2010. kein IF
5. Kölsch H, Heun R, Jessen F, Popp J, Hentschel F, Maier W, Lütjohann D. Alterations of
cholesterol precursor levels in Alzheimer's disease. Biochim Biophys Acta. 1801:945-950.
2010. IF: 5.269
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Professor Dr. med. Frank Olaf Jessen
6. Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese
JP, Al-Abed Y, Dodel R. The Role of Macrophage Migration Inhibitory Factor in Alzheimer’s
Disease. Mol Med. 16:116-121. 2010. IF: 3.757
7. Pentzek M, Wollny A, Wiese B, Jessen F, Haller F, Maier W, Riedel-Heller SG, Angermeyer
MC, Bickel H, Mösch E, Weyerer S, Werle J, Bachmann C, Zimmermann T, van den Bussche
H, Abholz HH, Fuchs A; AgeCoDe Study Group. Apart from nihilism and stigma: what
influences general practitioners' accuracy in identifying incident dementia? Am J Geriatr
Psychiatry. 17:965-975. 2010. IF: 3.638
8. Lewczuk P, Kornhuber J, Vanmechelen E, Peters O, Heuser I, Maier W, Jessen F, Bürger K,
Hampel H, Frölich L, Henn F, Falkai P, Rüther E, Jahn H, Luckhaus C, Perneczky R,
Schmidtke K, Schröder J, Kessler H, Pantel J, Gertz HJ, Vanderstichele H, De Meyer G,
Shapiro F, Wolf S, Bibl M, Wiltfang J. Amyloid beta peptides in plasma in early diagnosis of
Alzheimer's disease: a multicenter study with multiplexing. Exp Neurol. 223:366-367. 2010. IF:
4.699
9. Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H,
Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hüll M, Schröder J, Kessler H,
Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M,
Kornhuber J, Wiltfang J. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel
potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry. 15:138-145.
2010. IF: 13.668
Originalarbeiten: Mitglied in Autorengruppen
1. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith
AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S,
Longstreth WT Jr, Janssens AC, Pankratz VS, Dartigues JF, Hollingworth P, Aspelund T,
Hernandez I, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Antunez
C, Du Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J,
Varadarajan BN, Becker JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D,
Auerbach S, Rice K, Hofman A, Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty
BM, Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG, Wolf
PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM; CHARGE Consortium; GERAD1
Consortium; EADI1 Consortium. Genome-wide analysis of genetic loci associated with
Alzheimer disease. JAMA. 303:1832-1840. 2010. IF: 30.026
13

Professor Dr. med. Frank Olaf Jessen
2. Luck T, Riedel-Heller SG, Luppa M, Wiese B, Wollny A, Wagner M, Bickel H, Weyerer S,
Pentzek M, Haller F, Moesch E, Werle J, Eisele M, Maier W, van den Bussche H,
Kaduszkiewicz H; AgeCoDe Study Group. Risk factors for incident mild cognitive impairmentresults
from the German Study on Ageing, Cognition and Dementia in Primary Care Patients
(AgeCoDe). Acta Psychiatr Scand. 121:260-272. 2010. IF: 4.220
Übersichtsarbeiten
1. Jessen F. Stellungnahme zur S3-Leitlinie Demenzen der DGPPN und der DGN aus
psychiatrischer Sicht. Fortschr Neurol Psychiatr. 78:509-512. 2010. IF: 0.741
2. Maier W, Jessen F. Evidenzbasierte Standards für die Versorgung von Patienten mit
Demenzen. Nervenarzt. 81:795. 2010. IF: 0.681
3. Jessen F, Spottke A. Therapie von psychischen und Verhaltenssymptomen bei Demenz.
Nervenarzt. 81:815-816, 818-822. 2010. IF: 0.681
4. Hampel H, Frank R, Broich K, Teipel SJ, Katz RG, Hardy J, Herholz K, Bokde ALW, Jessen F,
Hoessler YC, Sanhai WR, Zetterberg H, Woodcock J, Blennow K. Biomarkers for treatment
trials and diagnosis in Alzheimer’s disease: academic, industry and regulatory perspectives.
Nat Rev Drug Discov. 9:560-574. 2010. IF: 29.008
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Bach JP, Spottke A, Jessen F, Dodel R. Rationale Behandlungsstrategien bei
Alzheimerdemenz. Was bremst die Flucht der Gedanken? Neurologie und Psychiatrie. 3:42-48.
2010.
2. Jessen F. Alzheimer Demenz. Der niedergelassene Arzt. 9:37-42. 2010.
3. Jessen F. Alzheimer-Krankheit: Neue Leitlinien und deren klinische Umsetzung. Current
congress. 9:14. 2010.
4. Jessen F. Bildgebende Verfahren in der Diagnostik von Demenzerkrankungen.
Nervenheilkunde. 29:758-760. 2010.
5. Jessen F, Maier W. Demenzerkrankungen. Pharma-Fokus ZNS. 9:24-28. 2010.
6. Maier W, Jessen F. Update Demenzen. Der Neurologe & Psychiater DNP. 10:2-4. 2010.
14

Professor Dr. med. Frank Olaf Jessen
Buchbeiträge
1. Jessen F. Psychiatrische Syndrome bei neurologischen Erkrankungen. In: Roter Faden
Neurologie, Eds. Dodel R, Klockgether T. Wissenschaftliche Verlagsgesellschaft Stuttgart. 709-
723. 2010. ISBN: 978-3-8047-2449-5
2. S3-Leitlinie Demenzen
Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN),
Deutsche Gesellschaft für Neurologie (DGN). Diagnose- und Behandlungsleitlinie Demenz.
Springer Verlag, Heidelberg. 2010. ISBN 978-3-642-13092-2
2009
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Schuhmacher A, von Widdern O, Guttenthaler V, Hofels S, Suliman H, Scheef L,
Block W, Urbach H, Maier W, Zobel. A. No association of the Val66Met polymorphism of the
brain-derived neurotrophic factor with hippocampal volume in major depression. Psychiatr
Genet. 19:99-101. 2009. IF: 2.581
2. Jessen F, Gür O, Block W, Ende G, Frölich L, Hammen T, Wiltfang J, Kucinski T, Jahn H,
Heun R, Maier W, Kölsch H, Kornhuber J, Träber F. A multicenter (1)H-MRS study of the
medial temporal lobe in AD and MCI. Neurology. 72:1735-1740. 2009. IF: 8.312
3. Popp J, Bacher M, Kölsch H, Noelker C, Deuster O, Dodel R, Jessen F. Macrophage migration
inhibitory factor in mild cognitive impairment and Alzheimer's disease. J Psychiatr Res. 43:749-
753. 2009. IF: 4.664
4. Block W, Träber F, von Widdern O, Metten M, Schild H, Maier W, Zobel A, Jessen F. Proton
MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive
disorder: correlates and predictors of treatment response. Int J Neuropsychopharmacol.
12:415-422. 2009. IF: 4.578
5. Popp J, Schaper K, Kölsch H, Cvetanovska G, Rommel F, Klingmüller D, Dodel R, Wüllner U,
Jessen F. CSF cortisol in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging.
30:498-500. 2009. IF: 6.189
15

Professor Dr. med. Frank Olaf Jessen
Originalarbeiten: Koautorenschaften
1. Zobel A, Schuhmacher A, Jessen F, Höfels S, von Widdern O, Metten M, Pfeiffer U, Hanses
C, Becker T, Rietschel M, Scheef L, Block W, Schild HH, Maier W, Schab SG. DNA-sequence
variants of the FKBP5 gene are associated with unipolar depression. Int J
Neuropsychopharmacol. 13:649-660. 2009. IF: 4.578
2. Ehreke L, Luppa M, Luck T, Wiese B, Weyerer S, Eifflaender-Gorfer S, Weeg D, Olbrich J, van
den Bussche H, Bachmann C, Eisele M, Maier W, Jessen F, Wagner M, Fuchs A, Pentzek M,
Angermeyer MC, König HH, Riedel-Heller SG; AgeCoDe group. Is the clock drawing test
appropriate for screening for mild cognitive impairment?--Results of the German study on
Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Dement Geriatr Cogn
Disord. 28:365-372. 2009. IF: 2.141
3. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, Singh Pahwa J,
Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan A, Lovestone S,
Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan
K, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD,
Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier M, Jessen F,
Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L,
Hampel H, Hül M, Rujescu D, Goate A, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo
K, Bettens K, Sleegers K, Engelborghs S, De Deyn P, van Broeckhoven C, Livingston G, Bass
NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M,
Singleton A, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N,
Wichmann HE, Carrasquillo MM, Pankratz SV, Younkin SG, Holmans P, O’Donovan M, Owen
MJ, Williams J. Genome-wide association study identifies variants at CLU and PICALM
associated with Alzheimer's disease, and shows evidence for additional susceptibility genes.
Nat Genet. 41:1088-1093. Erratum: 41:1156. 2009. IF: 35.532
4. Luck T, Riedel-Heller SG, Wiese B, Stein J, Weyerer S, Werle J, Kaduszkiewicz H, Wagner M,
Mösch E, Zimmermann T, Maier W, Bickel H, van den Bussche H, Jessen F, Fuchs A,
Pentzek M; für die AgeCoDe Study Group. CERAD-NP-Testbatterie: Alters-, geschlechts- und
bildungsspezifische Normen ausgewählter Subtests : Ergebnisse der German Study on
Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Z Gerontol Geriatr.
42:372-384. 2009. IF: 0.613
5. Klafki HW, Lewczuk P, Kamrowski-Kruck H, Maler JM, Müller K, Peters O, Heuser I, Jessen F,
Popp J, Frölich L, Wolf S, Prinz B, Luckhaus C, Schröder J, Pantel J, Gertz HJ, Kölsch H,
Müller BW, Esselmann H, Bibl M, Kornhuber J, Wiltfang J. Measurement of ERK 1/2 in CSF
16

Professor Dr. med. Frank Olaf Jessen
from Patients with Neuropsychiatric Disorders and Evidence for the Presence of the Activated
Form. J Alzheimers Dis. 18:613-622. 2009. IF: 3.745
6. Kölsch H, Wagner M, Bilkei-Gorzó A, Toliat MR, Pentzek M, Fuchs A, Kaduszkiewicz H, van
den Bussche H, Riedel-Heller SG, Angermeyer MC, Weyerer S, Werle J, Bickel H, Mösch E,
Wiese B, Daerr M, Jessen F, Maier W, Dichgans M. Gene polymorphisms in prodynorphin
(PDYN) are associated with episodic memory in the elderly. J Neural Transm. 116:897-903.
2009. IF: 2.730
7. Alexopoulos P, Günther F, Popp J, Jessen F, Peters O, Wolf S, Kneib T, Kurz A, Richter-
Schmidinger T, Lewczuk P, Bleich S, Wiltfang J, Kornhuber J. Plasma homocysteine and
cerebrospinal fluid neurodegeneration biomarkers in mild cognitive impairment and dementia. J
Am Geriatr Soc. 57:737-739. 2009. IF: 3.737
8. Kölsch H, Lütjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Friedrichs S, Maier TA,
Heun R. RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism.
J Cell Mol Med. 13:589-598. 2009. IF: 4.125
9. Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ, Kornhuber J, Frölich L,
Heuser I, Peters O, Wiese B, Kaduszkiewicz H, van den Bussche H, Hüll M, Kurz A, Rüther E,
Henn FA, Maier W. Association of SORL1 gene variants with Alzheimer's disease. Brain Res.
1264:1-6. 2009. IF: 2.728
10. Kornhuber J, Schmidtke K, Frolich L, Perneczky R, Wolf S, Hampel H, Jessen F, Heuser I,
Peters O, Weih M, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Pantel J, Rienhoff O,
Seuchter SA, Rüther E, Henn F, Maier W, Wiltfang J. Early and differential diagnosis of
dementia and mild cognitive impairment: design and cohort baseline characteristics of the
German Dementia Competence Network. Dement Geriatr Cogn Disord. 27:404-417. 2009. IF:
2.141
11. Kölsch H, Lütjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Schmitz S, Maier W, Heun
R. CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. Eur
Psychiatry. 24:183-190. 2009. IF: 2.766
12. Qureischie H, Heun R, Popp J, Jessen F, Maier W, Schmitz S, Hentschel F, Kelemen P,
Kölsch H. Association of CETP polymorphisms with the risk of vascular dementia and white
matter lesions. J Neural Transm. 116:467-472. 2009. IF: 2.730
13. Hong GS, Heun R, Jessen F, Popp J, Hentschel F, Kelemen P, Schulz A, Maier W, Kölsch H.
Gene variations in GSTM3 are a risk factor for Alzheimer's disease. Neurobiol Aging. 30:691-
696. 2009. IF: 6.189
17

Professor Dr. med. Frank Olaf Jessen
Originalarbeiten: Mitglied in Autorengruppen
1. Weyerer S, Schäufele M, Eifflaender-Gorfer S, Köhler L, Maier W, Haller F, Cvetanovska-
Pllashiniku G, Pentzek M, Fuchs A, van den Bussche H, Zimmermann T, Eisele M, Bickel H,
Mösch E, Wiese B, Angermeyer MC, Riedel-Heller SG; German AgeCoDe Study group.
Further members of the German AgeCoDe Study group. At-risk alcohol drinking in primary
care patients aged 75 years and older. Int J Geriatr Psychiatry. 24:1376-1385. 2009. IF: 2.419
2. Pentzek M, Fuchs A, Wiese B, Cvetanovska-Pllashniku G, Haller F, Maier W, Riedel-Heller
SG, Angermeyer MC, Bickel H, Mösch E, Weyerer S, Werle J, van den Bussche H, Eisele M,
Kaduszkiewicz H; AgeCoDe study group. General practitioners' judgment of their elderly
patients' cognitive status. J Gen Intern Med. 24:1314-1317. 2009. IF: 2.830
Fallberichte
1. Bach JP, Oertel WH, Dodel R, Jessen F. Treatment of hypersexuality in Parkinson's disease
with carbamazepine – a case report. Mov Disord. 24:1241-1242. 2009. IF: 4.505
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F. Bildgebende Verfahren in der Diagnostik der Alzheimer Demenz. Journal für
Neurologie, Neurochirurgie und Psychiatrie. 3:70-73. 2009.
2. Jessen F. Diagnostik von Demenzerkrankungen. Heilberufe.61:4. 2009.
3. Jessen F. Diagnostische Schärfe des Mini-Mental-Status Tests - Wann ist der Einsatz in der
Hausarztpraxis sinnvoll? Info Neurologie & Psychiatrie. 6:20-21. 2009.
4. Jessen F. Prävention und Frühbehandlung von Demenzen. Neuro Aktuell. 6:32-35. 2009.
5. Jessen F, Maier W, Spottke A, Deuschl G. S3-Leitlinie Demenzen: Eine integrative Leistung
zwischen Neurologie und Psychiatrie/Psychotherapie. MedReport. 44:15. 2009.
Buchbeiträge
18

Professor Dr. med. Frank Olaf Jessen
1. Jessen F, Hampel H. MRI as a surrogate marker in clinical trials in Alzheimer's Disease. In:
Imaging the aging brain, EDS. Jagust W, D'Esposito M. Oxford University Press. 305-318.
2009. ISBN: 978-0-19-532887-5
2. Jessen F. Liquordiagnostik. In: Diagnostik und Therapie von Demenzerkrankungen, Eds.
Mahlberg R, Gutzmann H. Deutscher Ärzteverlag. 153-156. 2009. ISBN: 978-3-7691-0563-6
3. Jessen F. Genetik. In: Diagnostik und Therapie von Demenzerkrankungen, Eds. Mahlberg R,
Gutzmann H. Deutscher Ärzteverlag. 157-160. 2009. ISBN: 978-3-7691-0563-6
2008
Originalarbeiten: Erst- und Letztautorenschaften
1. Tepest R, Wang L, Csernansky JG, Neubert P, Heun R, Scheef L, Jessen F. Hippocampal
surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's
dementia. Dement Geriatr Cogn Disord. 26:323-329. 2008. IF: 2.141
2. Schaper K, Kolsch H, Popp J, Wagner M, Jessen F. KIBRA gene variants are associated with
episodic memory in healthy elderly. Neurobiol Aging. 29:1123-1125. 2008. IF: 6.189
Originalarbeiten: Koautorenschaften
1. Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD,
Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach
TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H,
Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos
A, Stephan DA, Huentelman MJ. Evidence for an association between KIBRA and late-onset
Alzheimer's disease. Neurobiol Aging. 31:901-909. 2008. IF: 6.189
2. Qureischie H, Heun R, Lütjohann D, Popp J, Jessen F, Ledschbor-Frahnert C, Thiele H, Maier
W, Hentschel F, Kelemen P, Kölsch H. CETP polymorphisms influence cholesterol metabolism
but not Alzheimer's disease risk. Brain Res. 1232:1-6. 2008. IF: 2.728
3. Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Kornhuber J, Frölich L, Heuser I,
Peters O, Schulz JB, Schwab SG, Maier W. Influence of SORL1 gene variants: Association
with CSF amyloid-beta products in probable Alzheimer's disease. Neurosci Lett. 440:68-71.
2008. IF: 2.105
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Professor Dr. med. Frank Olaf Jessen
4. Kircher T, Weis S, Leube D, Freymann K, Erb M, Jessen F, Grodd W, Heun R, Krach S.
Anterior hippocampus orchestrates successful encoding and retrieval of non-relational
memory. An event-related fMRI study. Eur Arch Psychiatry Clin Neurosci. 258:363-372. 2008.
IF: 3.494
5. Leube DT, Weiss S, Freymann K, Erb M, Jessen F, Heun R, Grodd W, Kircher TT. Neuronal
correlates of verbal episodic memory in patients with MCI and Alzheimer’s Disease – a VBM
study. Int J Geriatr Psychiatry. 23:1114-1118. 2008. IF: 2.419
6. Hurlemann R, Jessen F, Wagner M, Ruhrmann S, Brockhaus A, Picker H, Scheef L, Block W,
Schild HH, Moller-Hartmann W, Krug B, Falkai P, Klosterkotter J, Maier W. Interrelated
neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental
state. Psychol Med. 38:843-851. 2008. IF: 6.159
7. Weyerer S, Eifflaender-Gorfer S, Köhler L, Jessen F, Maier W, Fuchs A, Pentzek M,
Kaduszkiewicz H, Bachmann C, Angermeyer MC, Luppa M, Wiese B, Mösch E, Bickel H.
Prevalence and risk factors for depression in non-demented primary care attenders aged 75
years and older. J Affect Disord. 111:153-163. 2008. IF: 3.517
8. Zobel A, Jessen F, von Widdern O, Schuhmacher A, Höfels S, Metten M, Rietschel M, Scheef
L, Block W, Becker T, H. Schild HH, Maier W, Schwab SG. Unipolar Depression and
Hippocampal Volume: Impact of DNA-sequence variants of the Glucocorticoid Receptor Gene.
Am J Med Genet B Neuropsychiatr Genet. 147B:836-843. 2008. IF: 3.705
9. Lewczuk P, Kornhuber J, Vanderstichele H, Vanmechelen E, Esselmann H, Bibl M, Wolf S,
Otto M, Reulbach U, Kölsch H, Jessen F, Schröder J, Schönknecht P, Hampel H, Peters O,
Weimer E, Perneczky R, Jahn H, Luckhaus C, Lamla U, Supprian T, Maler JM, Wiltfang J.
Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias
and MCI: A multicenter study. Neurobiol Aging. 29:812-818. 2008. IF: 6.189
10. Wüllner U, Gündisch D, Herzog H, Minnerop M, Joe A, Warnecke M, Jessen F, Schütz C,
Reinhardt M, Eschner W, Klockgether T, Schmaljohann J. Smoking upregulates alpha4beta2*
nicotinic acetylcholine receptors in the human brain. Neurosci Lett. 430:34-37. 2008. IF: 2.105
Übersichtsarbeiten
1. Jessen F. Neue Perspektiven der Bildgebung in der Diagnostik bei Demenzen. Nervenarzt. 79
Suppl 3:129-136. 2008. IF: 0.681
20

Professor Dr. med. Frank Olaf Jessen
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F. Vier Fragen zu Morbus Alzheimer. Medical Tribune. 43:13. 2008.
2. Maier W, Jessen F. Forschungsansätze in der Demenz. Neue Therapien sind absehbar.
Neurotransmitter. 19,Suppl. 2:18-23. 2008.
2007
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Wiese B, Cvetanovska G, Fuchs A, Kaduszkiewicz H, Kölsch H, Luck T, Mösch E,
Pentzek M, Riedel-Heller SG, Werle J, Weyerer S, Zimmermann T, Maier W, Bickel H. Patterns
of subjective memory impairment in the elderly: association with memory performance. Psychol
Med. 37:1753-1762. 2007. IF: 6.159
2. Popp J., Michael R. Freymann K, Jessen F. Häufigkeit und Risikofaktoren des
postpunktionellen Syndroms bei ambulanter Durchführung einer diagnostischen
Lumbalpunktion in der Gedächtnissprechstunde. Nervenarzt. 78:547-551. 2007. IF: 0.681
Originalarbeiten: Koautorenschaften
1. Luck T, Riedel-Heller SG, Kaduszkiewicz H, Bickel H, Jessen F, Pentzek M, Wiese B, Koelsch
H, van den Bussche H, Abholz HH, Moesch E, Gorfer S, Angermeyer MC, Maier W, Weyerer
S; AgeCoDe group. Mild cognitive impairment in general practice: age-specific prevalence and
correlate results from the German study on ageing, cognition and dementia in primary care
patients (AgeCoDe). Dement Geriatr Cogn Disord. 24:307-316. 2007. IF: 2.141
2. Kircher TT, Weis S, Freymann K, Erb M, Jessen F, Grodd W, Heun R, Leube DT.
Hippocampal activation in patients with mild cognitive impairment is necessary for successful
memory encoding. J Neurol Neurosurg Psychiatry. 78:812-818. 2007. IF: 4.764
3. Wiltfang J, Esselmann H, Bibl M, Hüll M, Hampel H, Kessler H, Frölich L, Schröder J, Peters O,
Jessen F, Luckhaus C, Perneczky R, Jahn H, Fiszer M, Maler JM, Zimmermann R,
Bruckmoser R, Kornhuber J, Lewczuk P. Amyloid beta peptide ratio 42/40 but not A beta 42
21

Professor Dr. med. Frank Olaf Jessen
correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. J Neurochem.
101:1053-1059. 2007. IF: 4.061
4. Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M,
Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R,
Jessen F, Kolsch H, Tsolaki M, Daniilidou M, Reiman EM, Papassotiropoulos A, Hutton ML,
Stephan DA, Craig DW. Identification of the genetic basis for complex disorders by use of
pooling-based genomewide single-nucleotide-polymorphism association studies. Am J Hum
Genet. 80:126-139. 2007. IF: 10.603
Fallberichte
1. Popp J, Thal D, Lewczuk P, Wiltfang J, Jessen F. Histologically confirmed amyloid deposition
and low CSF Aß42 in a cognitively normal subject. J Neurol. 254:970-971. 2007. IF: 3.473
Übersichtsarbeiten
1. Jessen F, Maier W. Ein Beitrag zur aktuellen Antidementiva-Diskussion in Deutschland.
Nervenarzt. 78:491-497. 2007. IF: 0.681
Buchbeiträge
1. Schmidtke K, Frölich L, Hüll M, Jessen F. Rahmenkonzept Demenz. In: Versorgungskonzepte
in der Neurologie, Eds: Meier U, Diener HC. Georg Thieme Verlag. 89-96. 2007. 978-3-13-
143671-9
2006
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Träber F, Freymann K, Maier W, Schild HH, Block W. Treatment monitoring and
response prediction with proton MR spectroscopy in AD. Neurology. 67:528-530. 2006. IF:
8.312
22

Professor Dr. med. Frank Olaf Jessen
2. Jessen F, Scherk H, Traber F, Theyson S, Berning J, Tepest R, Falkai P, Schild HH, Maier W,
Wagner M, Block W. Proton magnetic resonance spectroscopy in subjects at risk for
schizophrenia. Schizophr Res. 87:81-88. 2006. IF: 4.748
3. Traber F, Block W, Freymann N, Gur O, Kucinski T, Hammen T, Ende G, Pilatus U, Hampel H,
Schild HH, Heun R, Jessen F. A multicenter reproducibility study of single-voxel 1H-MRS of
the medial temporal lobe. Eur Radiol. 16:1096-1103. 2006. IF: 3.222
4. Jessen F, Feyen L, Freymann K, Tepest R, Maier W, Heun R, Schild HH, Scheef L. Volume
reduction of the entorhinal cortex in subjective memory impairment. Neurobiol Aging. 27:1751-
1759. 2006. IF: 6.189
Originalarbeiten: Koautorenschaften
1. Holzapfel J, Heun R, Lutjohann D, Jessen F, Maier W, Kolsch H. PPARD haplotype influences
cholesterol metabolism but is no risk factor of Alzheimer's disease. Neurosci Lett. 408:57-61.
2006. IF: 2.105
2. Heun R, Freymann K, Erb M, Leube DT, Jessen F, Kircher TT, Grodd W. Successful verbal
retrieval in elderly subjects is related to concurrent hippocampal and posterior cingulate
activation. Dement Geriatr Cogn Disord. 22:165-172. 2006. IF: 2.141
3. Teipel SJ, Ewers M, Dietrich O, Schoenberg SO, Jessen F, Heun R, Freymann N, Moller HJ,
Hampel H. Multizentrische Reliabilität MRT-gestützter Volumetrie des Gehirns. Nervenarzt.
77:1086-1095. 2006. IF: 0.681
4. Ewers M, Teipel SJ, Dietrich O, Schonberg SO, Jessen F, Heun R, Scheltens P, Pol LV,
Freymann NR, Moeller HJ, Hampel H. Multicenter assessment of reliability of cranial MRI.
Neurobiol Aging. 27:1051-1059. 2006. IF: 6.189
5. Kölsch H, Lutjohann D, Jessen F, Von Bergmann K, Schmitz S, Urbach H, Maier W, Heun R.
Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk
factor of Alzheimer's disease. Int J Mol Med. 17:791-794. 2006. IF: 1.573
6. Quednow BB, Jessen F, Kuhn KU, Maier W, Daum I, Wagner M. Memory deficits in abstinent
MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction. J
Psychopharmacol. 20:373-384. 2006. IF: 3.036
23

Professor Dr. med. Frank Olaf Jessen
7. Heun R, Freymann K, Erb M, Leube DT, Jessen F, Kircher TT, Grodd W. Mild cognitive
impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly.
Neurobiol Aging. 28:404-413. 2006. IF: 6.189
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F. Sind subjektive Gedächtnisstörungen ein Prodromalsyndrom der Demenz?
Nervenheilkunde. 26:659-661. 2007.
2. Jessen F, Maier W. Prognose von kognitiven Störungen im Alter. MedReport. 27:8. 2007.
3. Maier W, Jessen F. Was gibt es Neues in der Diagnostik von Demenzen? Surrogate-Marker
rücken in den Vordergrund. Notfall und Hausarztmedizin. 12:566-570. 2007.
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F. Demenzen. Der niedergelassene Arzt. 55:11-16. 2006.
2. Jessen F. Früherkennung von Demenzen - Bildgebung auch schon im Stadium der
subjektiven Gedächtnisstörungen auffällig. Neuro-Psychiatrische Nachrichten. 10:14. 2006.
3. Jessen F. Neue Befunde zur MR-Spektroskopie. Neuro-Psychiatrische Nachrichten. 10:13.
2006.
4. Jessen F, Frölich L, Schmidtke K, Hüll M. Die Herausforderung wird nur im Netzwerk zu
bewältigen sein. Neurologie & Psychiatrie. Sonderheft 1:30-32. 2006.
2005
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Traeber F, Freymann N, Maier W, Schild HH, Heun R, Block W. A comparative
study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's
disease. Dement Geriatr Cogn Disord. 20:178-183. 2005. IF: 2.141
2. Heun R, Kolsch H, Jessen F. Risk factors and early signs of Alzheimer's disease in a family
study sample Risk of AD. Eur Arch Psychiatry Clin Neurosci. 256:28-36. 2005. IF: 3.494
24

Professor Dr. med. Frank Olaf Jessen
Originalarbeiten: Koautorenschaften
1. Vollbach H, Heun R, Morris CM, Edwardson JA, McKeith IG, Jessen F, Schulz A, Maier W,
Kolsch H. APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Ann Neurol.
58:436-441. 2005. IF: 11.089
2. Schmaljohann J, Gundisch D, Minnerop M, Joe A, Bucerius J, Dittmar C, Jessen F, Guhlke S,
Wullner U. A simple and fast method for the preparation of n.c.a. 2-[(18)F]F-A85380 for human
use. Appl Radiat Isot. 63:433-435. 2005. IF: 1.172
3. Kölsch H, Lutjohann D, Jessen F, Urbach H, von Bergmann K, Maier W, Heun R.
Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of
Alzheimer's disease. J Neural Transm. 113:231-238. 2005. IF: 2.730
4. Heun R, Kolsch H, Jessen F. Risk factors and early signs of Alzheimer's disease in a family
study sample Risk of AD. Eur Arch Psychiatry Clin Neurosci. 256:28-36. 2005. IF: 3.494
5. Kolsch H, Jessen F, Freymann N, Kreis M, Hentschel F, Maier W, Heun R. ACE I/D
polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia. Neurosci
Lett. 377:37-39. 2005. IF: 2.105
Fallberichte
1. Freymann N, Michael R, Dodel R, Jessen F. Successful treatment of sexual disinhibition in
dementia with carbamazepine – a case report. Pharmacopsychiatry. 38:144-145. 2005. IF:
2.071
Deutschsprachige Publikationen (nicht in Pubmed gelistet)
1. Jessen F, Ewers M, Träber F, Teipel S, Gür O, Block W, Hampel H. Früh- und
Differenzialdiagnose von Demenzen - MR-Volumetrie und Protonen-MR-Spektroskopie.
Nervenheilkunde. 24:463-469. 2005.
2004
25

Professor Dr. med. Frank Olaf Jessen
Originalarbeiten: Erst- und Letztautorenschaften
1. Heun R, Ptok U, Kolsch H, Maier W, Jessen F. Contribution of apolipoprotein E and cathepsin
D genotypes to the familial aggregation of Alzheimer's disease. Dement Geriatr Cogn Disord.
18:151-158. 2004. IF: 2.141
Originalarbeiten: Koautorenschaften
1. Kolsch H, Linnebank M, Lutjohann D, Jessen F, Wullner U, Harbrecht U, Thelen KM, Kreis M,
Hentschel F, Schulz A, von Bergmann K, Maier W, Heun R. Polymorphisms in glutathione Stransferase
omega-1 and AD, vascular dementia, and stroke. Neurology. 63:2255-2260. 2004.
IF: 8.312
2. Heun R, Freymann N, Granath DO, Stracke CP, Jessen F, Barkow K, Reul J. Differences of
cerebral activation between superior and inferior learners during motor sequence encoding and
retrieval. Psychiatry Res. 132:19-32. 2004. IF: 2.964
3. Heun R, Ptok U, Kolsch H, Maier W, Jessen F. Contribution of apolipoprotein E and cathepsin
D genotypes to the familial aggregation of Alzheimer's disease. Dement Geriatr Cogn Disord.
18:151-158. 2004. IF: 2.141
4. Heun R, Erb, N, Jessen F, Klose, U, Granath D, Grodd W. 2004. Response-Related fMRI of
verdical and false recognition of words. Eur Psychiatry. 19:42-52. 2004. IF: 2.766
2003
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Scheef L, Germeshausen L, Tawo Y, Kockler M, Kuhn KU, Maier W, Schild HH,
Heun R. Reduced hippocampal activation during encoding and recognition of words in
schizophrenia patients. Am J Psychiatry. 160:1305-1312. 2003. IF: 12.539
Originalarbeiten: Koautorenschaften
1. Bagli M, Papassotiropoulos A, Hampel H, Becker K, Jessen F, Burger K, Ptok U, Rao ML,
Moller HJ, Maier W, Heun R. Polymorphisms of the gene encoding the inflammatory cytokine
interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in
26

Professor Dr. med. Frank Olaf Jessen
Alzheimer's disease Results of a pilot study. Eur Arch Psychiatry Clin Neurosci. 253:44-48.
2003. IF: 3.494
2. Hein S, Bonsignore M, Barkow K, Jessen F, Ptok U, Heun R. Lifetime depressive and somatic
symptoms as preclinical markers of late-onset depression. Eur Arch Psychiatry Clin Neurosci.
253:16-21. 2003. IF: 3.494
3. Ehl C, Kolsch H, Ptok U, Jessen F, Schmitz S, Frahnert C, Schlosser R, Rao ML, Maier W,
Heun R. Association of an interleukin-1beta gene polymorphism at position -511 with
Alzheimer's disease. Int J Mol Med. 11:235-238. 2003. IF: 1.573
2002
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Manka C, Scheef L, Granath DO, Schild HH, Heun R. Novelty detection and
repetition suppression in a passive picture viewing task: a possible approach for the evaluation
of neuropsychiatric disorders. Hum Brain Mapp. 17:230-236. 2002. IF: 5.880
Originalarbeiten: Koautorenschaften
1. Kolsch H, Lutjohann D, Ludwig M, Schulte A, Ptok U, Jessen F, von Bergmann K, Rao ML,
Maier W, Heun R. Polymorphism in the cholesterol 24S-hydroxylase gene is associated with
Alzheimer's disease. Mol Psychiatry. 7:899-902. 2002. IF: 13.668
2. Papassotiropoulos A, Lewis HD, Bagli M, Jessen F, Ptok U, Schulte A, Shearman MS, Heun
R. Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are
related to the exon 2 polymorphism of the cathepsin D gene. Neuroreport. 13:1291-1294. 2002.
IF: 1.656
3. Block W, Jessen F, Traber F, Flacke S, Manka C, Lamerichs R, Keller E, Heun R, Schild H.
Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic
resonance spectroscopic imaging in patients with Alzheimer disease. Arch Neurol. 59:828-834.
2002. IF: 7.584
Übersichtsarbeiten
27

Professor Dr. med. Frank Olaf Jessen
1. Block W, Traber F, Flacke S, Jessen F, Pohl C, Schild H. In-vivo proton MR-spectroscopy of
the human brain: Assessment of N-acetylaspartate (NAA) reduction as a marker for
neurodegeneration. Amino Acids. 23:317-323. 2002. IF: 3.248
2001
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Flacke S, Granath DO, Manka C, Scheef L, Papassotiropoulos A, Schild HH, Heun
R. Encoding and retrieval related cerebral activation in continuous verbal recognition. Brain
Res Cogn Brain Res. 12:199-206. 2001. IF: 2.884
2. Jessen F, Block W, Traber F, Keller E, Flacke S, Lamerichs R, Schild HH, Heun R. Decrease
of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients. Neurology.
57:930-932. 2001. IF: 8.312
3. Jessen F, Fries T, Kucharski C, Nishimura T, Hoenig K, Maier W, Falkai P, Heun R. Amplitude
reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia.
Neurosci Lett. 309:185-188. 2001. IF: 2.105
4. Jessen F, Kucharski C, Fries T, Papassotiropoulos A, Hoenig K, Maier W, Heun R. Sensory
gating deficit expressed by a disturbed suppression of the P50 event- related potential in
patients with Alzheimer's disease. Am J Psychiatry. 158:1319- 1321. 2001. IF: 12.539
Originalarbeiten: Koautorenschaften
1. Ptok U, Seeher C, Jessen F, Papassotiropoulos A, Heun R. Inter-rater reliability of family
history information on psychiatric disorders in relatives. Eur Arch Psychiatry Clin Neurosci.
251:279-283. 2001. IF: 3.494
2. Bonsignore M, Barkow K, Jessen F, Heun R. Validity of the five-item WH Well-Being Index
(WHO-5) in an elderly population. Eur Arch Psychiatry Clin Neurosci. 251 Suppl 2:II27-31.
2001. IF: 3.494
3. Papassotiropoulos A, Lutjohann D, Bagli M, Locatelli S, Jessen F, Buschfort R, Ptok U,
Bjorkhem I, von Bergmann K, Heun R. 24S-hydroxycholesterol in cerebrospinal fluid is
elevated in early stages of dementia. J Psychiatr Res. 36:27-32. 2001. IF: 4.664
28

Professor Dr. med. Frank Olaf Jessen
4. Heun R, Papassotiropoulos A, Jessen F, Maier W, Breitner JC. A family study of Alzheimer
disease and early- and late-onset depression in elderly patients. Arch Gen Psychiatry. 58:190-
196. 2001. IF: 12.016
2000
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Block W, Traber F, Keller E, Flacke S, Papassotiropoulos A, Lamerichs R, Heun R,
Schild HH. Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the
medial temporal lobe of patients with AD. Neurology. 55:684-688. 2000. IF: 8.312
2. Jessen F, Heun R, Erb M, Granath DO, Klose U, Papassotiropoulos A, Grodd W. The
concreteness effect: evidence for dual coding and context availability. Brain Lang. 74:103-112.
2000. IF: 3.115
Originalarbeiten: Koautorenschaften
1. Heun R, Jessen F, Klose U, Erb M, Granath D, Freymann N, Grodd W. Interindividual variation
of cerebral activation during encoding and retrieval of words. Eur Psychiatry. 15:470-479. 2000.
IF: 2.766
2. Bagli M, Papassotiropoulos A, Jessen F, Schmitz S, Rao ML, Maier W, Heun R. Identical
distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer
disease and controls in a German population. Am J Med Genet. 96:775-777. 2000. IF: 2.479
3. Heun R, Jessen F, Klose U, Erb M, Granath DO, Grodd W. Response-related fMRI analysis
during encoding and retrieval revealed differences in cerebral activation by retrieval success.
Psychiatry Res. 99:137-150. 2000. IF: 2.964
4. Papassotiropoulos A, Bagli M, Becker K, Jessen F, Maier W, Rao ML, Ludwig M, Heun R. No
association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's
disease. Int J Mol Med. 6:587-589. 2000. IF: 1.573
5. Majores M, Bagli M, Papassotiropoulos A, Schwab SG, Jessen F, Rao ML, Maier W, Heun R.
Allelic association between the D10S1423 marker and Alzheimer's disease in a German
population. Neurosci Lett. 289:224-226. 2000. IF: 2.105
29

Professor Dr. med. Frank Olaf Jessen
6. Papassotiropoulos A, Bagli M, Jessen F, Maier W, Forstl H, Kurz A, Heun R. Interaction of two
genes possibly involved in the regulation of the amyloid precursor protein (APP) processing.
Mol Psychiatry. 5:240-241. 2000. IF: 13.668
7. Papassotiropoulos A, Lutjohann D, Bagli M, Locatelli S, Jessen F, Rao ML, Maier W, Bjorkhem
I, von Bergmann K, Heun R. Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal
degeneration and potential state marker for Alzheimer's disease. Neuroreport. 11:1959-1962.
2000. IF: 1.656
8. Papassotiropoulos A, Bagli M, Jessen F, Frahnert C, Rao ML, Maier W, Heun R. Confirmation
of the association between bleomycin hydrolase genotype and Alzheimer's disease. Mol
Psychiatry. 5:213-215. 2000. IF: 13.668
9. Burgmer M, Jessen F, Freyberger HJ. Polythetic diagnostic approach to the borderline
personality disorder. the valency of the single criterion in the concept of professional therapists.
Psychopathology. 33:119-124. 2000. IF: 1.816
10. Bagli M, Papassotiropoulos A, Knapp M, Jessen F, Rao L, Maier W, Heun R. Association
between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's
disease risk in a German population. Neurosci Lett. 283:109-112. 2000. IF: 2.105
11. Lutjohann D, Papassotiropoulos A, Bjorkhem I, Locatelli S, Bagli M, Oehring RD, Schlegel U,
Jessen F, Rao ML, von Bergmann K, Heun R. Plasma 24S-hydroxycholesterol (cerebrosterol)
is increased in Alzheimer and vascular demented patients. J Lipid Res. 41:195-198. 2000. IF:
5.559
12. Bagli M, Papassotiropoulos A, Jessen F, Rao ML, Maier W, Heun R. Gene-gene interaction
between interleukin-6 and alpha2-macroglobulin influences the risk for Alzheimer's disease.
Ann Neurol. 47:138-139. 2000. IF: 11.089
1999
Originalarbeiten: Erst- und Letztautorenschaften
1. Jessen F, Erb M, Klose U, Lotze M, Grodd W, Heun R. Activation of human language
processing brain regions after the presentation of random letter strings demonstrated with
event-related functional magnetic resonance imaging. Neurosci Lett. 270:13-16. 1999. IF:
2.105
30

Professor Dr. med. Frank Olaf Jessen
Originalarbeiten: Koautorenschaften
1. Heun R, Klose U, Jessen F, Erb M, Papassotiropoulos A, Lotze M, Grodd W. Functional MRI
of cerebral activation during encoding and retrieval of words. Hum Brain Mapp. 8:157-169.
1999. IF: 5.880
2. Schwab SG, Bagli M, Papassotiropoulos A, Jessen F, Maier W, Rao ML, Heun R. Alpha-1antichymotrypsin
gene polymorphism and risk for sporadic Alzheimer's disease in a German
population. Dement Geriatr Cogn Disord. 10:469-472. 1999. IF: 2.141
3. Bagli M, Papassotiropoulos A, Schwab SG, Jessen F, Rao ML, Maier W, Heun R. No
association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease
in a German population. J Neurol Sci. 167:34-36. 1999. IF: 2.353
4. Papassotiropoulos A, Bagli M, Jessen F, Rao ML, Schwab SG, Heun R. Early onset and lateonset
depression are independent of the genetic polymorphism of apolipoprotein E. Dement
Geriatr Cogn Disord. 10:258-261. 1999. IF: 2.141
5. Papassotiropoulos A, Bagli M, Jessen F, Bayer TA, Maier W, Rao ML, Heun R. A genetic
variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk
for sporadic Alzheimer's disease. Ann Neurol. 45:666-668. 1999. IF: 11.089
6. Papassotiropoulos A, Bagli M, Feder O, Jessen F, Maier W, Rao ML, Ludwig M, Schwab SG,
Heun R. Genetic polymorphism of cathepsin D is strongly associated with the risk for
developing sporadic Alzheimer's disease. Neurosci Lett. 262:171-174. 1999. IF: 2.105
1998
Originalarbeiten: Erst- und Letztautorenschaften
1. Heun R, Papassotiropoulos A, Jessen F. The validity of psychometric instruments for detection
of dementia in the elderly general population. Int J Geriatr Psychiatry. 13:368-380. 1998. IF:
2.419
Originalarbeiten: Koautorenschaften
1. Cobbers JM, Wolter M, Reifenberger J, Ring GU, Jessen F, An HX, Niederacher D, Schmidt
EE, Ichimura K, Floeth F, Kirsch L, Borchard F, Louis DN, Collins VP, Reifenberger G.
31

Professor Dr. med. Frank Olaf Jessen
Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL. Brain Pathol. 8:263-
276. 1998. IF: 3.995
32