ALKALOID BIOSYNTHESIS IN PLANTS: Biochemistry, Cell ... - UFV

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32 FACCHINI TABLE 1 Alkaloid biosynthetic enzymes for which the corresponding genes have been cloned Enzyme Function Species Type Reference Monoterpenoid indole alkaloid biosynthesis TDC Tryptophan decarboxylase Catharanthus roseus Pyridoxal-5 ′ -phospahate- 31 dependent decarboxylase Camptotheca acuminata 91 STR Strictosidine synthase Catharanthus roseus Vacuolar glycoprotein 104 Rauwolfia serpentina 84 SGD Strictosidine β- D-glucosidase Catharanthus roseus Membrane-associated 55 glucosidase T16H Tabersonine 16-hydroxylase Catharanthus roseus P450-dependent 151 monooxygenase D4H Desacetoxyvindoline 4-hydroxylase Catharanthus roseus 2-Oxoglutarate-dependent 176 dioxygenase DAT Deacetylvindoline acetyltransferase Catharanthus roseus Acetyl CoA-dependent 164 acetyltransferase Benzylisoquinoline alkaloid biosynthesis TYDC Tyrosine decarboxylase Papaver somniferum Pyridoxal-5 ′ -phospahate- 38 dependent decarboxylase 6OMT Norcoclaurine Coptis japonica S-Adenosyl-L-methionine- 114 6-O-methyltransferase dependent O-methyltransferase 4 ′ OMT 3 ′ -Hydroxy-N- Coptis japonica S-Adenosyl-L-methionine- 114 methylcoclaurine dependent O-methyltransferase 4 ′ -O-methyltransferase OMT II;1-4 Norcoclaurine Thalictrum tuberosum S-Adenosyl-L-methionine- 49 6-O-methyltransferase dependent O-methyltransferase
CYP80A1 Berbamunine synthase Berberis stolonifera P450-dependent 81 monooxygenase CYP80B1 N-Methylcoclaurine 3 ′ - Eschscholzia californica P450-dependent 133 -hydroxylase monooxygenase Papaver somniferum 72, 182 BBE Berberine bridge enzyme Eschscholzia californica Flavinylated oxidoreductase 34 Papaver somniferum 41 Berberis stolonifera 21 ALKALOID BIOSYNTHESIS IN PLANTS 33 SOMT Scoulerine Coptis japonica S-Adenosyl-L-methionine- 171 9-O-methyltransferase dependent O-methyltransferase COR Codeinone reductase Papaver somniferum Aldo/keto reductase 173 Tropane alkaloid and nicotine biosynthesis ODC Ornithine decarboxylase Datura stamonium Pyridoxal-5 ′ -phospahate- 112 dependent decarboxylase PMT Putrescine Atropa belladonna S-Adenosyl-L-methionine- 167 N-methyltransferase dependent N-methyltransferase Nicotina tabacum 71 TR-I Tropinone reductase-I Datura stramonium Short-chain dehydrogense 119 TR-II Tropinone reductase-II Datura stramonium Short-chain dehydrogenase 119 H6H Hyoscyamine Hyoscyamus niger 2-Oxoglutarate-dependent 101 6β-hydroxylase dioxygenase Atropa belladonna 168 Purine alkaloid biosynthesis CS Caffeine synthase Camellia sinensis S-Adenosyl-L-methionine- – dependent N-methyltransferase
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ALKALOID BIOSYNTHESIS IN PLANTS: Biochemistry, Cell ... - UFV

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