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2007, Piran, Slovenia

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Cold water immersion<br />

thermogenesis (Lesná et al. 1999) than that mediated by both β1 and β2 adrenoceptors, the<br />

role of other types of adrenoceptors can be anticipated. Heart rate increased after<br />

administration of the β2 agonist, but was not influenced by the β1 agonist. The role of β2<br />

adrenoceptors in mediating heart rate was also attenuated after cold adaptation. Data indicate<br />

that downregulation of adrenoceptors plays a crucial role in regulation of physiological<br />

functions responsible for adaptation of humans to cold.<br />

ACKNOWLEDGEMENT<br />

This study was financially supported by the Priessnitz Spa in Jeseník, Czech Rep.<br />

REFERENCES<br />

Janský P. Janský L.2002. Sites and cellular mechanisms of human adrenergic thermogenesis -<br />

a review. J. Thermal Biology, 27, 269-277.<br />

Janský L., Uličný B., Šrámek P., Hošek V., Heller J., Pařízková J. 1996. Changes in<br />

thermal homeostasis in humans due to repeated cold water immersions. Pflügers Arch.-<br />

Eur. J. Physiol., 432, 368- 3372.<br />

Lesná I., Vybíral. S., Janský L., Zeman V., 1999. Human nonshivering thermogenesis. J.<br />

Thermal Biol., 24, 63-69.<br />

Vybíral S., Janský L., Lesná I., Zeman V. 2000. Thermoregulation in polar swimmers and<br />

physiological significance of human adrenergic thermogenesis. Experimental Physiology,<br />

85, 321-324.<br />

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