2007, Piran, Slovenia

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Environmental Ergonomics XII Igor B. Mekjavic, Stelios N. Kounalakis & Nigel A.S. Taylor (Eds.), © BIOMED, Ljubljana <strong>2007</strong> EFFECT OF ANTI-MOTION SICKNESS DRUGS ON MOTION SICKNESS-INDUCED PREDISPOSITION TO HYPOTHERMIA Gerard Nobel 1 , Ola Eiken 2 , Arne Tribukait 2 , Roger Kölegård 2 , Igor B. Mekjavic 3 1 Royal Netherlands Navy, Nethertlands 2 Swedish Defense Research Agency, Karolinska Institute, Berzelius v. 13, SE-17177 Stockholm, Sweden 3 Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Jamova 39, SI-1000, Ljubljana, Slovania Contact person: nobel_gerard@hotmail.com INTRODUCTION Previous studies have shown that motion sickness (MS) potentiates the cooling rate of the body core during immersion, both in luke-warm water (28°C) 1 and cold water (15°C) 2 . The aim of the present study was to investigate whether it is possible to influence this MSinduced predisposition to hypothermia by administering two commonly used anti-MS drugs, namely the histamine-receptor blocker dimenhydrinate (Amosyt®) and the muscarinereceptor blocker scopolamine (Scopoderm®). METHODS The study was approved by the Human Ethics Committee at the Karolinska Institute. After giving their informed consent 9 healthy male subjects participated in 5 experimental conditions. The subjects’ mean (range) age, weight, and length were 25 (23-27) year, 73 (60- 83) kg and 1.80 (1.68-1.87) m, respectively. After baseline recording and administration of certain combinations of the two drugs and their respective placebo substances each subject was immersed in 15°C water for a maximum of 90 minutes or till the core temperature had dropped 2°C or had reached 35°C. The experimental conditions were: 1. Control: no MS provocation, no medication. 2. Control MS: MS provocation, no medication. 3. Placebo MS: placebo Amosyt® and placebo Scopoderm®, MS provocation . 4. Amo MS: Amosyt® medication, MS provocation. 5. Scop MS: Scopoderm® medication, MS provocation. MS provocation was induced by the use of a rotating chair in combination with a regimen of standardized head movements. Throughout the experiments rectal temperature, mean skin temperature, the difference in temperature between forearm and 3 rd finger of the right hand, oxygen uptake, heart rate and blood pressure were recorded, but only the results of the rectal temperature are presented here. At 5-min intervals (after MS provocation) each subject rated motion sickness, thermal comfort and temperature perception. RESULTS AND DISCUSSION Amosyt® and Scopoderm® were similarly efficacious in ameliorating nausea during and after the MS provocation. During immersion the core cooling rate (∆ rectal temperature) was 28 % greater in the MS control condition than in the Control condition (p
Cold water immersion REFERENCES Mekjavic IB, Tipton MJ, Gennser M & Eiken O. (2001). Motion sickness potentiates core cooling during immersion in humans. J Physiol 535, 619-623. Nobel G, Eiken O, Tribukait A, Kolegard R & Mekjavic IB. (2006). Motion sickness increases the risk of accidental hypothermia. Eur J Appl Physiol 98, 48-55. 331
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ENVIRONMENTAL ERGONOMICS XII Procee
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ENVIRONMENTAL ERGONOMICS XII Procee
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International Conferences on Enviro
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TABLE OF CONTENTS Table of contents
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Table of contents ALTITUDE ATTENUAT
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Table of contents TOWARDS PREVENTIO
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Table of contents RATE AFFECT EXERC
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Table of contents Uroš Dobnikar, S
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Table of contents TO A HOT ENVIRONM
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Table of contents Andreas D. Flouri
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Table of contents PHYSICAL FITNESS
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Table of contents ESTIMATION OF THE
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Herman Potocnic Lecture the advanta
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Invited presentation Gravitational
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Gravitational Physiology SKELETAL M
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Lf (mm) 50.0 40.0 30.0 20.0 10.0 Fa
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Gravitational Physiology maximum is
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Gravitational Physiology THERMOREGU
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Gravitational Physiology THE EXERCI
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Gravitational Physiology Since exer
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Gravitational Physiology During the
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Gravitational Physiology CARDIOVASC
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as observed at rest after LBNP was
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Gravitational Physiology THERMOREGU
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Gravitational Physiology THE EFFECT
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Gravitational Physiology Fortney SM
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Gravitational Physiology Contractil
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Gravitational Physiology Edgerton V
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Diving Physiology A library of imag
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Diving Physiology Information recal
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Diving Physiology RESULTS Figure 1
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Diving Physiology sensitivity is no
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Diving Physiology Physiological Mea
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Diving Physiology same sequence. Th
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Diving Physiology HYPERVENTILATION
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Diving Physiology software. Individ
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Diving Physiology REFERENCES IMCA.
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Diving Physiology recorded (MIE Med
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Diving Physiology DISCUSSION The ma
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Altitude Physiology vastus laterali
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Altitude Physiology IS INTERMITTENT
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Altitude Physiology Table 2: Lactat
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Altitude Physiology CARBOHYDRATE IN
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Altitude Physiology Figure 1: Mean
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Altitude Physiology HYPOXIA INDUCED
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Altitude Physiology Figure 1. Mean
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Altitude Physiology ANALYSIS OF MUS
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SOL MG TA BF VM Altitude Physiology
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Altitude Physiology LOAD CARRIAGE I
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Table 2: Differential ratings of pe
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Altitude Physiology EFFECTS OF INTE
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Cerebral deoxy-Hb (delta, µM) Cere
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Altitude Physiology ENDURANCE RESPI
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Altitude Physiology Wylegala JA, Pe
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Invited presentation Cognitive and
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Cognitive and Psycophysiological Fu
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Cognitive and psychophysiological f
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CLOTHING AND TEXTILE SCIENCE 131
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Clothing SPACER FABRICS IN OUTDOOR
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F i / g m -2 4,0 3,5 3,0 2,5 2,0 1,
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Clothing TOTAL EVAPORATIVE RESISTAN
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9,0 8,0 7,0 6,0 5,0 4,0 3,0 2,0 1,0
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Clothing DIFFERENCES IN CLOTHING IN
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Clothing parallel It values ranged
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Clothing CORRELATION BETWEEN SUBJEC
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Clothing and left side chest, scapu
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Clothing studies using an ice vest
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Insulation (Clo) (Clo) Clo / kg 6 5
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Clothing EFFECTS OF MOISTURE TRANSP
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Clothing the P plots above 60%RH (p
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Clothing EFFECT OF CLOTHING INSULAT
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Clothing EFFECTS OF QUILT AND MATTR
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38 33 28 23 18 0 30 60 90 120 150 m
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Clothing German) were measured, and
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Clothing Metabolism decreased and w
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Clothing Table 1. Comparison of ski
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Clothing PHYSIOLOGICAL RESPONSES AT
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Clothing underwear at 25 °C in per
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Clothing REDUCTION OF HEAT STRESS I
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Clothing THE INTERACTION BETWEEN PH
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Relative humidity (%) Clothing Figu
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Clothing DEVELOPMENT OF THE “WEAR
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Clothing EFFECTS OF AIR GAPS UNDER
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Temper at ur e( ˇ ć) 28.5 27.5 26
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Personal protective equipment Invit
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Personal protective equipment fabri
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Personal protective equipment PHYSI
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Mean skin temperature (ºC) 38.0 37
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Personal protective equipment the S
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Personal protective equipment DISCU
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Personal protective equipment Final
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Personal protective equipment REFER
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Personal protective equipment Tc wa
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Personal protective equipment level
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F i / g m -2 300 250 200 150 100 50
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h M / % 90 80 70 60 50 40 activity
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Personal protective equipment 0.05
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Personal protective equipment was u
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Personal protective equipment THERM
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Personal protective equipment the s
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Personal protective equipment the c
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Personal protective equipment wette
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Table 1 1. Properties of the tested
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Personal protective equipment HEAT
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Personal protective equipment Profi
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Personal protective equipment PHYSI
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Personal protective equipment REDUC
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39.0 38.5 38.0 37.5 37.0 36.5 40.0
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Personal protective equipment EXERC
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Personal protective equipment appro
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Personal protective equipment Table
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Personal protective equipment reduc
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Invited presentation Non-thermal fa
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Non-thermal factors heat loss by al
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Non-thermal factors DOES A FATIGUE-
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Non-thermal factors cycling, despit
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Non-thermal factors INDIVIDUAL VARI
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Non-thermal factors to some categor
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Non-thermal factors RATES OF TOTAL
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Non-thermal factors CHANGES IN BLOO
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Non-thermal factors Table 1. Thresh
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Non-thermal factors THE DIFFERENCE
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Water intake(g) 2000 1800 1600 1400
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Non-thermal factors IMPROVED FLUID
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Non-thermal factors A tendency for
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Sweating Table 1: Sweat gland count
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Sweating Taylor, N.A.S. (2000). Reg
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Sweating back/waist area and finall
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Figure 1: A chrome dome following p
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Sweating Such differences could be
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Sweating the forearm and thigh skin
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Page 289 and 290: Sweating SWEATY HANDS: DIFFERENCES
Page 291 and 292: Sweating Figure 2: Inter-site sweat
Page 293 and 294: Sweating REGIONAL DIFFERENCES IN TO
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Page 299 and 300: Sweating RESULTS On average, the ma
Page 301 and 302: Sweating THE SWEAT SECRETION AND SO
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Page 305 and 306: Invited presentation FINGER COLD IN
Page 307 and 308: Cold physiology INTRA-INDIVIDUAL DI
Page 309 and 310: Cold physiology number was estimate
Page 311 and 312: Cold physiology cold receptors decr
Page 313 and 314: Cold physiology EFFECT OF URAPIDIL
Page 315 and 316: Cold physiology THE EFFECT OF EXERC
Page 317 and 318: TRAINABILITY OF COLD INDUCED VASODI
Page 319 and 320: Cold physiology REFERENCES Adams, T
Page 321 and 322: Cold physiology THE EFFECT OF REPEA
Page 323 and 324: Cold physiology THE EFFECT OF ALTIT
Page 325 and 326: Cold physiology SKIN SURFACE MENTHO
Page 327 and 328: Cold physiology COGNITIVE PERFORMAN
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Page 333 and 334: Cold water immersion the formula: M
Page 335 and 336: Cold water immersion REFERENCES Cho
Page 337 and 338: Cold water immersion were: 1 metre
Page 339 and 340: Cold water immersion surf beaches.
Page 341 and 342: Cold water immersion Table 1. Break
Page 343 and 344: Cold water immersion ARM INSULATION
Page 345 and 346: Cold water immersion RESULTS Experi
Page 347 and 348: Cold water immersion thermogenesis
Page 349 and 350: Cold water immersion The other comp
Page 351 and 352: Cold water immersion REFERENCES And
Page 353 and 354: Thermal comfort THERMAL SENSATIONS
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Page 357 and 358: Thermal comfort and heart rate usin
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Page 365 and 366: Thermal comfort limit of exposure d
Page 367 and 368: Table 2: Statistical summary. Gende
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Page 371 and 372: Thermal comfort RELATION BETWEEN TH
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Page 375 and 376: Thermal comfort THE EVALUATION OF T
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Page 379 and 380: time(min) Thermal comfort WHY DO JA
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Thermal comfort TCT : THERMAL COMFO
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Thermal comfort INTERNATIONAL STAND
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Acute and chronic heat exposure PHY
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Acute and chronic heat exposure Fig
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Acute and chronic heat exposure EFF
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Acute and chronic heat exposure 2.2
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Acute and chronic heat exposure EFF
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Acute and chronic heat exposure A N
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Acute and chronic heat exposure of
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Acute and chronic heat exposure PHY
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Acute and chronic heat exposure Tab
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Acute and chronic heat exposure INT
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probability plot 99 95 80 60 40 20
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Acute and chronic heat exposure HAN
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Acute and chronic heat exposure ALL
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Acute and chronic heat exposure Tab
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Acute and chronic heat exposure UNC
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Thermal Sensation Scale 10 9 8 7 6
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Acute and chronic heat exposure RES
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Acute and chronic heat exposure eve
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Acute and chronic heat exposure 30%
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Acute and chronic heat exposure REF
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RADIANT FLOW THROUGH BICYCLE HELMET
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Figure 2. Difference in heat transf
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Manikins DEVELOPMENT OF A LYING DOW
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IT = 6.45( _ ,Tsk - _ ,Tair)/(Q/A)
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Manikins cases. If the body is even
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Heat balance components 100% 80% 60
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Manikins clothing system. This effe
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Manikins The coupled system was val
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Manikins A NOVEL APPROACH TO MODEL-
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Manikins THERMAL MANIKIN EVALUATION
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SR (g/min) Figure 2. Predictive mod
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ESTIMATION OF COOLING EFFECT OF ICE
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Manikins Figure 3: Comparison among
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Manikins EVALUATION OF THE ARMY BOO
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Ty [Nm] 60 50 40 30 20 10 0 0 5 10
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Manikins different black 100% cotto
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Manikins REFERENCES Bogerd, C.P., H
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Modelling RESULTS From this kind of
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Modelling (T , T , V& , ) = 1. 0 +
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NORMALIZED CVCL 8 7 6 5 4 3 2 1 0 M
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Modelling illustrated in Figure 1.
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Modelling MODELLING PATIENT TEMPERA
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Modelling Figure 1: Blood and mean
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Modelling simulations the additiona
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Modelling Table 1. Descriptive summ
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Modelling concomitant increase in b
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Modelling REFERENCES 1. U.S. Depart
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Modelling from the 1988 population.
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Modelling somatotypes in multivaria
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Modelling Each scan data was first
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Modelling The line through the data
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Hip( width) −Waist ( width ) HW
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Modelling measurements are extracte
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Measurement methods not included in
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Measurement methods humidity. The o
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Measurement methods DISCUSSION Base
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Air film Skin surface Skin layer δ
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Measurement methods and calculated
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Rectal temperature ( o C) 39.5 39.0
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Measurement methods work rates, and
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Measurement methods HUMIDEX: CAN TH
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Measurement methods highlighted. In
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Invited presentation Universal Ther
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Universal Thermal Climate Index dat
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Universal Thermal Climate Index DYN
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Universal Thermal Climate Index DIS
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Universal Thermal Climate Index COM
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Skin temperature (°C) Universal Th
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Universal Thermal Climate Index PRO
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Universal Thermal Climate Index The
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Universal Thermal Climate Index ASS
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Universal Thermal Climate Index ima
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Universal Thermal Climate Index min
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Working environment EFFECTS OF LIGH
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Working environment It is interesti
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30 25 20 15 10 5 0 25 12 Working en
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Working environment ERGONOMICS OPTI
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Working environment astigmatism, an
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Working environment RESULTS The hig
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Working environment hearing protect
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Working environment Redistribution
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Working environment DISCUSSION Thes
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Working Environment over the phone
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Working Environment DISCUSSION Diff
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Working Environment results, conclu
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Working Environment BP as the refer
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Working Environment significantly a
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Working Environment responses betwe
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Working Environment Casualty handli
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Working Environment REFERENCES Davi
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Working Environment RESULTS The sub
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Temperature (C) 35 33 31 29 27 25 2
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Working Environment METHODS Student
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Working Environment ANTHROPOGENIC I
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Working Environment RESULTS The res
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Employment Standards VISUAL ACUITY
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Employment Standards Results are pr
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Employment Standards to spend free
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Occupational Thermal Problems and d
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Occupational Thermal Problems HEAT
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Occupational Thermal Problems some
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Occupational Thermal Problems HORSE
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Occupational Thermal Problems range
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Occupational Thermal Problems PHYSI
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Occupational Thermal Problems DISCU
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Occupational Thermal Problems recom
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DLEmin [hours] 7,0 6,0 5,0 4,0 3,0
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Occupational Thermal Problems EFFEC
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Occupational Thermal Problems PERIP
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Occupational Thermal Problems durin
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Occupational Thermal Problems PRODU
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Time (hours) 4 3,5 3 2,5 2 1,5 1 0,
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Occupational Thermal Problems (Suun
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Occupational Thermal Problems highl
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Occupational Thermal Problems and o
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1) estimated (208 - 0.7 x age) *P
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Occupational Thermal Problems of a
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Occupational Thermal Problems tempe
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Table 1: Environmental conditions o
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Occupational Thermal Problems The h
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Occupational Thermal Problems RESUL
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Occupational Thermal Problems PHYSI
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Occupational Thermal Problems corre
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Occupational Thermal Problems DEVEL
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Occupational Thermal Problems All i
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A Adolfsson Niklas 540 Ainslie Phil
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Kim Myung-Ju 409 Kim Taegyou 189 Kl
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Sormunen Erja 599 Spindler Uli 145
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SPONSOR 641
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