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2007, Piran, Slovenia

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Cerebral deoxy-Hb (delta, µM)<br />

Cerebral t-Hb (delta, µM)<br />

Muscle deoxy-Hb (delta, µM)<br />

Muscle t-Hb (delta, µM)<br />

A<br />

15<br />

10<br />

5<br />

0<br />

-5<br />

-10<br />

B<br />

20<br />

15<br />

10<br />

5<br />

0<br />

-5<br />

-10<br />

A<br />

20<br />

15<br />

10<br />

5<br />

0<br />

-5<br />

-10<br />

B<br />

20<br />

15<br />

10<br />

5<br />

0<br />

IHE<br />

0 20 40 60 80 100<br />

Exercise Intensity (VO2peak)<br />

IHE<br />

.<br />

*<br />

*<br />

*<br />

*<br />

Placebo<br />

0 20 40 60 80 100<br />

Exercise Intensity (VO2peak)<br />

Placebo<br />

-5<br />

0 20 40 60 80 100 0 20 40 60 80 100<br />

. .<br />

Exercise Intensity (% VO2peak) Exercise Intensity (% VO2peak)<br />

Altitude Physiology<br />

Relative to baseline, heavy exercise following IHE resulted in an increased cerebral<br />

deoxy-Hb (P = 0.02) (Figure 2A) and oxy-Hb (P = 0.03, data not shown), and a<br />

lowered TOI (P = 0.04, data not shown), with no change in t-Hb (Figure 2B).<br />

Cerebral oxygenation was similar between baseline and post-intervention exercise<br />

tests in the placebo group.<br />

.<br />

Figure 2. Changes in<br />

cerebral deoxy-Hb and t-<br />

Hb during incremental<br />

exercise at baseline<br />

(closed circles) and 2-days<br />

post intervention (open<br />

circles). * difference from<br />

baseline (P < 0.05).<br />

Values are mean (SD).<br />

Figure 3. Changes in<br />

muscle deoxy-Hb and t-<br />

Hb during incremental<br />

exercise at baseline<br />

(closed circles) and 2-days<br />

post intervention (open<br />

circles). * difference from<br />

baseline (P < 0.05).<br />

Values are mean (SD).<br />

103

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