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jlor:9rfr rs.'!ll1 oKj o lVt Table 1: Oral hypoglycemlc drus Class Drug Iro-F.+ 6Ji,r15 J#i8 &\t dS s;LAg.;l.r Sulfonylureas Chlorpropamide Gliclazide Glimepiride Glibenclamide Glipizide Tolbutamide Biguanides Metformin Glucmidase inhibitots Acarbose Meglitinides Repaglinide Thiazolidinediones Pioglitazone * Approved but not marketed .ujc* 0FlJlSg4$l&r'l+ Rosiglitazone ds ."1!og3lo Table 2: Sorne medlcadons lhat cqn ralse blood glucose Drug Probable mechanlsm Clonidine Adrenergic action Clozapine ? Impain insulin secretion Corticosteroids Oppose insulin action Diuretics ("specially thiazides) Oppose insulin action Nicotinic acid ? Opposes insulin action Nifedipine (but not other calcium antagonists) Delavs insulin action Oral contraceptive hormones Oppose insulin action Phenytoin Blocks insnlin secretion Phenothiazines Not known Sugar-containing qyrups (e.g. antibiotics/cough mixtures) Note: Clinical relevance of some effects in uncertain Increased glucose intake
tVY e ,rjLp91b t,,.!Jlt."Uij -o;S.* 0F S unAB t3"! asorta3;l.r Table 3: Some nedlcatlons that may lower blood glucose Drug Sugested nechanlsm ACE inhibitors Increase insulin action Alcohol lnhibits hepatic glucose Fibrates Not known Monoamine oxidase Not Inoqm production and release Qninins (? quinidine) Increases insulin secretion Salicylates Qarge dose) Not known Note: Clinical relevance of some effects is uncertain
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