J.'.~"";i'
J.'.~"";i' J.'.~"";i'
INTRODUCTION AND AIM OF THE WORK
Introduction Introduction Preeclampsia is a serious complication ofthe second halfof pregnancy that occurs with a frequency of5% to 15% . This disease is a leading cause of fetal growth retardation, infant and maternal morbidity and mortality. In the placental bed, fibrin and platelet deposition, thrombosis, and infarction occur and result in reduced placental perfusion . In severe disease disseminated intravascular coagulation may be present with platelet and fibrin deposition in many organs, including the brain, liver , and kidneys . Altered coagulability may be important in the pathogenesis ofpreeclampsia. (Robets, 1993) . Lipoprotein (a), a circulating lipoprotein particle, has been found to enhance blood coagulation by competing with plasminogen for its binding sites on fibrin clots and endothelial cells. This action is believed to be mediated by a structural homology (> 90%) between apoliopoprotcin (a) which is the carrier protein for lipoprotein (a) and plasminogen. The activation of plasminogen to form plasmin is the essential step necessary for the lysis of fibrin by plasmin (Dahlen, 1994). Many studies had demonstrated that elevated lipoprotein (a) levels are associated with atherogenesis and myocardial infarction. (Wang, et al. 1994) . Both in vitro and in vivo data indicate that lipoprotein (a) levels are elevated in preeclampsia and associated with the severity ofthe disease. This hypothesis is supported by observation of high lipoprotein (a) levels in a single family with two cases of severe preeclampsia. (Husby et al., 1996) . I
- Page 3 and 4: ACKNOWLEDGMENT Above all and first
- Page 5: List of Abbreviations : Apolipoprot
- Page 10 and 11: Aim of The Work Aim ofthe work Is t
- Page 12 and 13: I . HYPERTENSIVE DISORDERS IN PREGN
- Page 15: -f Etiology of Preeclampsia Review
- Page 18 and 19: Pathogenesis of pre- eclampsia Revi
- Page 20 and 21: -.-- Review ofLiterature Changes in
- Page 22 and 23: --f' -,- Review ofLiterature clinic
- Page 24 and 25: Review ofLiterature and is consider
- Page 27 and 28: Review ofLiterature next pregnancy
- Page 29 and 30: Review ofLiterature On the other ha
- Page 31 and 32: Review ofLiterature which is define
- Page 34 and 35: 1. Gestational hypertension (withou
- Page 36: Review ofLiterature However, severe
- Page 40 and 41: Review ofLiterature It is an indica
- Page 42: Review ofLiterature above hemodynam
- Page 45: Review ofLiterature patients (Nahee
- Page 49: Proteinuria and microalbuminuria :
- Page 55: Review ofLiterature peptides includ
INTRODUCTION<br />
AND<br />
AIM OF THE WORK
Change language