Analytical and Forensic Toxicology
Analytical and Forensic Toxicology Analytical and Forensic Toxicology
Post Mortem Changes “Necrokinetics” • Postmortem interval • Defined by the degree of decomposition • Decomposition • Autolysis: enzymes are released and chemicals move down gradients • Putrefacation: digestion by bacteria • Anthropophagia: feeding on remains
Specimens • Blood • Reported as “blood concentrations” • From femoral or subclavian (low glucose) • Right heart blood (elevated glucose) • Vitreous • Avascular, acellular so well protected • Aqueous content > blood • Urine • Bladder serves as a “reservoir”
- Page 37 and 38: TLC Goldfranks 9th edition
- Page 39 and 40: TLC Drawbacks • Multiple steps
- Page 41 and 42: Reverse phase chromatography • No
- Page 43 and 44: HPLC
- Page 45 and 46: Gas Chromatography • Expensive
- Page 47 and 48: Mass Spectrometry • Can serve as
- Page 49 and 50: MS Limits • Cannot separate enant
- Page 51 and 52: GC/MS • Expensive equipment • M
- Page 53 and 54: Hair Analysis • Hair grows ~1 cm/
- Page 55 and 56: • Amphetamines • Cannabinoids
- Page 57 and 58: • • • • • Tetrahydrocanna
- Page 59 and 60: • Dronabinol • Efavirenz • NS
- Page 61 and 62: “Poppy Seed” Defense 6-MAM
- Page 63 and 64: Methadone False Positives • Queti
- Page 65 and 66: • Benzodiazepines Metabolized to
- Page 67 and 68: Nasal Inhalers • Can contain l-me
- Page 69 and 70: Federal Cutoffs (ng/mL) Substance S
- Page 71 and 72: Specimen Validity • Appearance
- Page 73 and 74: In Vitro Adulteration “Add after
- Page 75 and 76: Others • Acids and bases (i.e. le
- Page 77 and 78: Questions?
- Page 79 and 80: Butrylcholinesterase • Malnutriti
- Page 81 and 82: Anion Gap Reliability • Hypercalc
- Page 83 and 84: • • • Forensics Aid medical /
- Page 85 and 86: Medical Review Officer • • Lice
- Page 87: Post Mortem Toxicology
- Page 91 and 92: Other sources
- Page 93 and 94: Legal Ethanol
- Page 95 and 96: The Barman’s Paradox • Legally
- Page 97 and 98: 1. Wide turns 2. Straddling / drivi
- Page 99 and 100: What’s in a Drink? • 10 oz beer
- Page 101 and 102: • Specific gravity 0.8 g/ml • V
- Page 103 and 104: • • • • • • “Breathan
- Page 105: Photo References 1. http://www.offt
Specimens<br />
• Blood<br />
• Reported as “blood concentrations”<br />
• From femoral or subclavian (low glucose)<br />
• Right heart blood (elevated glucose)<br />
• Vitreous<br />
• Avascular, acellular so well<br />
protected<br />
• Aqueous content > blood<br />
• Urine<br />
• Bladder serves as a “reservoir”
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