Analytical and Forensic Toxicology

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Laboratories • Clinical Laboratory Improvement Amendments of 1988 (CLIA) • Medical Lab Testing governed by federal regulations since 1992 • Regulations apply to all lab testing of human specimens for medical purposes • All tests require the possession of an appropriate certificate
• Waived • Moderate complexity • High complexity Testing Moderate Record Keeping Written Procedures Laboratory Director Competency Testing Proficiency Testing Controls Inspection High Qualified onset supervisor Daily review of all results
Page 1 and 2: Analytical and Forensic Evan S. Sch
Page 3: Content • Core Content of Medical
Page 7 and 8: Magic Answer Box? • Old methodolo
Page 9 and 10: Testing “You’re fired, Jack. Th
Page 11 and 12: Assay Methods • Chromatography
Page 13 and 14: • Salicylates • • • Spot Te
Page 15 and 16: Co-oximetry • Spectrophotometry u
Page 17 and 18: Spectrochemical • Produce light a
Page 19 and 20: Immunoassays • Created due to nee
Page 21: Non-competitive “Sandwich” assa
Page 29 and 30: Competitive From Goldfranks 9th edi
Page 31 and 32: Immunoassays • Old - radio immuno
Page 33 and 34: Magnetic Microparticle Goldfranks 9
Page 35 and 36: Rf = Rf migration distance of subst
Page 37 and 38: TLC Goldfranks 9th edition
Page 39 and 40: TLC Drawbacks • Multiple steps
Page 41 and 42: Reverse phase chromatography • No
Page 43 and 44: HPLC
Page 45 and 46: Gas Chromatography • Expensive
Page 47 and 48: Mass Spectrometry • Can serve as
Page 49 and 50: MS Limits • Cannot separate enant
Page 51 and 52: GC/MS • Expensive equipment • M
Page 53 and 54: Hair Analysis • Hair grows ~1 cm/
Page 55 and 56:
• Amphetamines • Cannabinoids
Page 57 and 58:
• • • • • Tetrahydrocanna
Page 59 and 60:
• Dronabinol • Efavirenz • NS
Page 61 and 62:
“Poppy Seed” Defense 6-MAM
Page 63 and 64:
Methadone False Positives • Queti
Page 65 and 66:
• Benzodiazepines Metabolized to
Page 67 and 68:
Nasal Inhalers • Can contain l-me
Page 69 and 70:
Federal Cutoffs (ng/mL) Substance S
Page 71 and 72:
Specimen Validity • Appearance
Page 73 and 74:
In Vitro Adulteration “Add after
Page 75 and 76:
Others • Acids and bases (i.e. le
Page 77 and 78:
Questions?
Page 79 and 80:
Butrylcholinesterase • Malnutriti
Page 81 and 82:
Anion Gap Reliability • Hypercalc
Page 83 and 84:
• • • Forensics Aid medical /
Page 85 and 86:
Medical Review Officer • • Lice
Page 87 and 88:
Post Mortem Toxicology
Page 89 and 90:
Specimens • Blood • Reported as
Page 91 and 92:
Other sources
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Legal Ethanol
Page 95 and 96:
The Barman’s Paradox • Legally
Page 97 and 98:
1. Wide turns 2. Straddling / drivi
Page 99 and 100:
What’s in a Drink? • 10 oz beer
Page 101 and 102:
• Specific gravity 0.8 g/ml • V
Page 103 and 104:
• • • • • • “Breathan
Page 105:
Photo References 1. http://www.offt
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Analytical and Forensic Toxicology

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