Analytical and Forensic Toxicology

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• Howard Greller • Jeffrey Brent • Adhi Sharma • Chuck McCay • Kent Olson Special Thanks! It was the break they had been waiting for; prints left at the crime scene
Content • Core Content of Medical Toxicology • Part 5: Analytical and Forensic Toxicology • LLSA Articles • Post-mortem Toxicology: What the dead can and cannot tell us. Clin Tox 2003;41(1):47-56. • Is this urine really negative? J of Sub Abus Treat 207;33:33-42.
Page 1: Analytical and Forensic Evan S. Sch
Page 5 and 6: • Waived • Moderate complexity
Page 7 and 8: Magic Answer Box? • Old methodolo
Page 9 and 10: Testing “You’re fired, Jack. Th
Page 11 and 12: Assay Methods • Chromatography
Page 13 and 14: • Salicylates • • • Spot Te
Page 15 and 16: Co-oximetry • Spectrophotometry u
Page 17 and 18: Spectrochemical • Produce light a
Page 19 and 20: Immunoassays • Created due to nee
Page 21: Non-competitive “Sandwich” assa
Page 29 and 30: Competitive From Goldfranks 9th edi
Page 31 and 32: Immunoassays • Old - radio immuno
Page 33 and 34: Magnetic Microparticle Goldfranks 9
Page 35 and 36: Rf = Rf migration distance of subst
Page 37 and 38: TLC Goldfranks 9th edition
Page 39 and 40: TLC Drawbacks • Multiple steps
Page 41 and 42: Reverse phase chromatography • No
Page 43 and 44: HPLC
Page 45 and 46: Gas Chromatography • Expensive
Page 47 and 48: Mass Spectrometry • Can serve as
Page 49 and 50: MS Limits • Cannot separate enant
Page 51 and 52: GC/MS • Expensive equipment • M
Page 53 and 54:
Hair Analysis • Hair grows ~1 cm/
Page 55 and 56:
• Amphetamines • Cannabinoids
Page 57 and 58:
• • • • • Tetrahydrocanna
Page 59 and 60:
• Dronabinol • Efavirenz • NS
Page 61 and 62:
“Poppy Seed” Defense 6-MAM
Page 63 and 64:
Methadone False Positives • Queti
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• Benzodiazepines Metabolized to
Page 67 and 68:
Nasal Inhalers • Can contain l-me
Page 69 and 70:
Federal Cutoffs (ng/mL) Substance S
Page 71 and 72:
Specimen Validity • Appearance
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In Vitro Adulteration “Add after
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Others • Acids and bases (i.e. le
Page 77 and 78:
Questions?
Page 79 and 80:
Butrylcholinesterase • Malnutriti
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Anion Gap Reliability • Hypercalc
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• • • Forensics Aid medical /
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Medical Review Officer • • Lice
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Post Mortem Toxicology
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Specimens • Blood • Reported as
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Other sources
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Legal Ethanol
Page 95 and 96:
The Barman’s Paradox • Legally
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1. Wide turns 2. Straddling / drivi
Page 99 and 100:
What’s in a Drink? • 10 oz beer
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• Specific gravity 0.8 g/ml • V
Page 103 and 104:
• • • • • • “Breathan
Page 105:
Photo References 1. http://www.offt
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Analytical and Forensic Toxicology

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