Analytical and Forensic Toxicology

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Sample Calculation 50 kg man drinks 1 shot of 80 proof alcohol 1.5 oz (30 ml/oz) = 45 ml 40% of 45 ml = 18 ml 18 ml X 0.8 g/ml = 16 g which is 16,000 mg 50 kg (0.6 L/kg) = 30 L (10 dL /L) = 300 dL 16,000 mg/300 dL = 80 mg/dL
• • • • • • “Breathanol” [expired air] surragote for [blood] (sort of) • Henry’s law [ethanol] remains constant throughout respiratory tract Mean breath:blood ratio 1:2100 used in forensics Many confounders [Breath ethanol] mmol/L X 2100 = [Blood ethanol] mmol/L Breath units underestimate BAC
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Analytical and Forensic Evan S. Sch
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Content • Core Content of Medical
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• Waived • Moderate complexity
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Magic Answer Box? • Old methodolo
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Testing “You’re fired, Jack. Th
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Assay Methods • Chromatography
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• Salicylates • • • Spot Te
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Co-oximetry • Spectrophotometry u
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Spectrochemical • Produce light a
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Immunoassays • Created due to nee
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Non-competitive “Sandwich” assa
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Competitive From Goldfranks 9th edi
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Immunoassays • Old - radio immuno
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Magnetic Microparticle Goldfranks 9
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Rf = Rf migration distance of subst
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TLC Goldfranks 9th edition
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TLC Drawbacks • Multiple steps
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Reverse phase chromatography • No
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HPLC
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Gas Chromatography • Expensive
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Mass Spectrometry • Can serve as
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MS Limits • Cannot separate enant
Page 51 and 52: GC/MS • Expensive equipment • M
Page 53 and 54: Hair Analysis • Hair grows ~1 cm/
Page 55 and 56: • Amphetamines • Cannabinoids
Page 57 and 58: • • • • • Tetrahydrocanna
Page 59 and 60: • Dronabinol • Efavirenz • NS
Page 61 and 62: “Poppy Seed” Defense 6-MAM
Page 63 and 64: Methadone False Positives • Queti
Page 65 and 66: • Benzodiazepines Metabolized to
Page 67 and 68: Nasal Inhalers • Can contain l-me
Page 69 and 70: Federal Cutoffs (ng/mL) Substance S
Page 71 and 72: Specimen Validity • Appearance
Page 73 and 74: In Vitro Adulteration “Add after
Page 75 and 76: Others • Acids and bases (i.e. le
Page 77 and 78: Questions?
Page 79 and 80: Butrylcholinesterase • Malnutriti
Page 81 and 82: Anion Gap Reliability • Hypercalc
Page 83 and 84: • • • Forensics Aid medical /
Page 85 and 86: Medical Review Officer • • Lice
Page 87 and 88: Post Mortem Toxicology
Page 89 and 90: Specimens • Blood • Reported as
Page 91 and 92: Other sources
Page 93 and 94: Legal Ethanol
Page 95 and 96: The Barman’s Paradox • Legally
Page 97 and 98: 1. Wide turns 2. Straddling / drivi
Page 99 and 100: What’s in a Drink? • 10 oz beer
Page 101: • Specific gravity 0.8 g/ml • V
Page 105: Photo References 1. http://www.offt
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Analytical and Forensic Toxicology

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