Analytical and Forensic Toxicology
Analytical and Forensic Toxicology Analytical and Forensic Toxicology
Laboratory Methods • Enzymatic • ADH + ETOH = NADH (340 nm) • FP with elevated lactate (lactate converted to pyruvate increases NADH formation) • GC • Can detect other volatiles (“toxic”)
• Specific gravity 0.8 g/ml • Vd 0.6 L/kg • 1-1.5 shot(s) = 30 ml • mmol/L = (mg/dL)/4.6 • % = grams/100 ml The Numbers
- Page 49 and 50: MS Limits • Cannot separate enant
- Page 51 and 52: GC/MS • Expensive equipment • M
- Page 53 and 54: Hair Analysis • Hair grows ~1 cm/
- Page 55 and 56: • Amphetamines • Cannabinoids
- Page 57 and 58: • • • • • Tetrahydrocanna
- Page 59 and 60: • Dronabinol • Efavirenz • NS
- Page 61 and 62: “Poppy Seed” Defense 6-MAM
- Page 63 and 64: Methadone False Positives • Queti
- Page 65 and 66: • Benzodiazepines Metabolized to
- Page 67 and 68: Nasal Inhalers • Can contain l-me
- Page 69 and 70: Federal Cutoffs (ng/mL) Substance S
- Page 71 and 72: Specimen Validity • Appearance
- Page 73 and 74: In Vitro Adulteration “Add after
- Page 75 and 76: Others • Acids and bases (i.e. le
- Page 77 and 78: Questions?
- Page 79 and 80: Butrylcholinesterase • Malnutriti
- Page 81 and 82: Anion Gap Reliability • Hypercalc
- Page 83 and 84: • • • Forensics Aid medical /
- Page 85 and 86: Medical Review Officer • • Lice
- Page 87 and 88: Post Mortem Toxicology
- Page 89 and 90: Specimens • Blood • Reported as
- Page 91 and 92: Other sources
- Page 93 and 94: Legal Ethanol
- Page 95 and 96: The Barman’s Paradox • Legally
- Page 97 and 98: 1. Wide turns 2. Straddling / drivi
- Page 99: What’s in a Drink? • 10 oz beer
- Page 103 and 104: • • • • • • “Breathan
- Page 105: Photo References 1. http://www.offt
Laboratory Methods<br />
• Enzymatic<br />
• ADH + ETOH = NADH (340 nm)<br />
• FP with elevated lactate (lactate<br />
converted to pyruvate increases<br />
NADH formation)<br />
• GC<br />
• Can detect other volatiles (“toxic”)
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