Desmopressin (GWAHS) - Intensive Care & Coordination Monitoring ...
Desmopressin (GWAHS) - Intensive Care & Coordination Monitoring ...
Desmopressin (GWAHS) - Intensive Care & Coordination Monitoring ...
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ADULT A CRITICAL C CARE C SERVICE S INTRAVENOUS I DRUG D PROTOCOLS<br />
P<br />
DESMOPRESSIN ACETATE - DDAVP Reviewed: May, 2005<br />
TRADE NAME<br />
ACTIONS<br />
INDICATIONS<br />
DOSAGE<br />
ADVERSE<br />
REACTIONS<br />
PRECAUTIONS<br />
SPECIAL<br />
REQUIREMENTS<br />
Minirin<br />
(This information is to be used as a guide only. Please refer to product insert for<br />
further information)<br />
Increases coagulant activity of Factor VIII as well as the<br />
Von Willebrand Factor, plasminogen activator is also<br />
released<br />
Vasodilation<br />
Antidiuretic effect: increases H2O re-absorption in the renal<br />
collecting tubule (acts on V1 receptors only)<br />
Bleeding in patients with uraemia, congenital or drug<br />
induced platelet dysfunction. (Maximum effect within 4<br />
hours of dose)<br />
Diabetes Insipidus, including that induced by brain death /<br />
head injury<br />
0.3 - 0.4 mcg/kg as a stat dose as ordered by Medical<br />
Officer.<br />
Doses greater than 4mcg must be diluted only in 100ml<br />
N/S and infuse over 20 minutes<br />
NB: Much lower doses used for Diabetes Insipidus.<br />
1 to 4 mcg daily in divided doses. Start at 0.5mcg IV stat.<br />
Dose related:<br />
Tachycardia, decrease in diastolic BP<br />
Headache, nausea, vomiting, mild abdominal cramps<br />
Nasal congestion, facial flushing, vulval pain,<br />
H2O intoxication from over hydration.<br />
Use with caution in patients with cardiovascular disease<br />
and the elderly.<br />
<strong>Care</strong> must be taken to prevent fluid overload in patients at<br />
risk of raised ICP.<br />
Continuous ECG monitoring<br />
Infusion pump and giving set<br />
Strict fluid balance (hourly input / output measurement)<br />
Daily electrolyte measurement when initiating therapy<br />
Daily weight<br />
Page 1 of 2<br />
Created: May, 2005<br />
Team/nursing/wards/icu/ policies/medication protocols/ DESMOPRESSIN ACETATE<br />
Reviewed and adapted fro use at OBH / BBH CCS with acknowledgement to Hornsby-Ku-ring-gai ICU
ADULT A CRITICAL C CARE C SERVICE S INTRAVENOUS I DRUG D PROTOCOLS<br />
P<br />
DESMOPRESSIN ACETATE - DDAVP Reviewed: May, 2005<br />
OBSERVATIONS<br />
REFERENCES<br />
APPROVED<br />
BP and HR every 15 min for the first hour then hourly as<br />
usual for ICU patients<br />
MIMS on line 2005<br />
Australian Injectable Drugs Handbook<br />
John Lambert – Area Director of Critical <strong>Care</strong> Service<br />
Page 2 of 2<br />
Created: May, 2005<br />
Team/nursing/wards/icu/ policies/medication protocols/ DESMOPRESSIN ACETATE<br />
Reviewed and adapted fro use at OBH / BBH CCS with acknowledgement to Hornsby-Ku-ring-gai ICU
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