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michigan hypertension core curriculum - State of Michigan

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eadings were higher than150/96 mm Hg. His parents are both hypertensive on medication and<br />

he used their home BP monitor with a large cuff and it was 150/96 and 164/104 mmHg. What<br />

would be your starting therapy?<br />

A. Hydrochlorothiazide (diuretic) 25mg qd<br />

B. Valsartan (angiotensin receptor blocker) 320mg qd<br />

C. Metoprolol XL (extended release beta blocker) 50mg qd<br />

D. Amlodipine (dihydropyridine calcium channel blocker) 5mg qd<br />

E. Amlodipine/lotensin (dihydropyridine calcium channel blocker + ACE inhibitor)<br />

5/20mg qd (Correct answer)<br />

Essential Points:<br />

• Blood pressure is inherently variable within a predictable range. Hypertension is defined as<br />

elevated average BP over time, preferably with a minimum <strong>of</strong> 3 properly performed readings on<br />

different days and is never based on a single measurement<br />

o Proper measurement <strong>of</strong> BP includes that the patient is seated in a chair with a backrest<br />

and have their feet resting on the floor and be resting for a minimum <strong>of</strong> 5 minutes. Most<br />

importantly, a proper sized cuff should be used and unfortunately most Americans now<br />

need the larger cuff due to the increase in obesity.<br />

• Hypertension is classified into different categories.<br />

o Pre-<strong>hypertension</strong> are BP readings between 120-139/80-89 mmHg<br />

o Mixed systolic/diastolic <strong>hypertension</strong> is most common in middle aged patients when both<br />

the diastolic and systolic BP are elevated above 140/90 mmHg at the <strong>of</strong>fice. It is due to<br />

increased arteriolar resistance in the distal smaller vessels.<br />

o Isolated systolic <strong>hypertension</strong> is most common after 50 years old. It is due to increased<br />

large conduit (aorta) vessel stiffness.<br />

o Isolated diastolic <strong>hypertension</strong> is the least common and least risky <strong>hypertension</strong><br />

phenotype.<br />

o White Coat Hypertension (<strong>of</strong>fice <strong>hypertension</strong>) when the patient has elevated <strong>of</strong>fice<br />

BP (>140/90 mmHg), however outside the <strong>of</strong>fice the BP is 140/90 mmHg) accounts for 77% <strong>of</strong> people who have a first<br />

stroke, 74% who have congestive heart failure, and 69% who have a first heart attack.<br />

o Normotensive men and women at 50 years <strong>of</strong> age live approximately 5 years longer than<br />

their normotensive counterparts.<br />

NKFM & MDCH 23

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