michigan hypertension core curriculum - State of Michigan

clonidine (Catapres†) 0.1–0.8 mg PO BID
clonidine patch (Catapres-TTS) 0.1–0.3 mg TD weekly
methyldopa (Aldomet†) 250–1,000 mg PO BID
reserpine (generic) 0.1–0.25 mg PO daily
guanfacine (Tenex†) 0.5–2 mg PO daily
In summary, there are a number of drug classes for clinicians to choose from to treat patients.
Which class or classes of medications are used depends on what compelling indications the patient
has for a specific class and which side effects are likely to be well tolerated and also, quite importantly,
which drug classes work most effectively with each other. There has been a progressive appearance
of new drug classes over the last sixty years and we are likely to continue to see additional medications
added to the anti-hypertensive regimen as drug development continues.
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enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-
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2997.
2. Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee
on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7
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8. Philipp T, Anlauf M, Distler A, Holzgreve H, Michaelis J, Wellek S. Randomised, double
blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in
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9. Turnbull F, Neal B, Algert C, et al. Effects of different blood pressure-lowering regimens on major
cardiovascular events in individuals with and without diabetes mellitus: results of prospectively
designed overviews of randomized trials. Arch Intern Med. Jun 27 2005;165(12):1410-1419.
10. Major cardiovascular events in hypertensive patients randomized to doxazosin vs
202 Hypertension Core Curriculum