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Study of respiratory symptoms among sputum positive

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£Jisctt.fsion<br />

Table (33) showed, mean induration <strong>of</strong>tuberculin test in smear +ve<br />

-»---- 17.5 mm was highly significant than in smear -ve 13.2 mm cases, in this<br />

study +ve tuberculin test in smear -ve cases can be explained as most <strong>of</strong><br />

them were BCG vaccinated, or they get infection and diseased.<br />

When clinical <strong>symptoms</strong> presentation in smear +ve cases were<br />

compared as regard tuberculin test results (tab. 34) no any <strong>symptoms</strong> was<br />

significantly different, and in agreement with this results Garnal EI Din<br />

(1997) found the same result. Their was non significant association<br />

between tuberculin skin test and smoking <strong>among</strong> cases with smear +ve or<br />

smear -ve for APB. But tuberculin test positvity was higher in non smoker<br />

79.7% than in smoker 72.2% in smear +ve cases, also Garnal EI Din<br />

(1997) found lower reactivity in smoker than in non smoker and this can be<br />

explained by Sibille and Reynolds (1990) as tobacco smoke could alter<br />

native and acquired resistance to mycobacterial tubercle bacilli, and<br />

exposure to tobacco smoke causes morphological and functional changes in<br />

the alveolus macrophage with multiple defects in macrophage/monocyte<br />

and CD4 lymphocyte immune responses. The smoking recognized as a<br />

toxic factor capable <strong>of</strong> reducing host defense (Cr<strong>of</strong>ton et al., 1992).<br />

In this study their was non significant difference <strong>of</strong> BCG vaccination<br />

between smear +ve (88.3%) and smear -ve (81.3%) (tab. 36), but<br />

percentage was higher in smear +ve cases than in smear -ve this explained<br />

as BCG has lower degree in protection. Also Altet et al. (1993) concluded<br />

that, the low degree <strong>of</strong> protection afforded by the BeG vaccination<br />

program, and the known harmful effects it causes, make this method <strong>of</strong><br />

little value, and not advisable in tuberculosis programs, also Murhekar et<br />

al. (1995), revealed the similar conclusion that III VIew <strong>of</strong> the low<br />

protective effectiveness <strong>of</strong> BeG vaccination against pulmonary<br />

126

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