Organ Specific Guide - Raintree Nutrition, Inc

AMAZON CALM SUPPORT
Description: A synergistic formula of rainforest botanicals traditionally used in South America for their
nervine, sedative and calming properties.
Traditional uses by organ or system: Brain/CNS: For stress, anxiety, and disturbed sleep patterns.
Ingredients: A proprietary blend of mulungu (Erythrina mulungu), manacá (Brunfelsia uniflora), piri-piri
(Cyperus articulatus), graviola (Annona muricata), catuaba (Erythroxylum catuaba), iporuru (Alchornea
castaneifolia), ubos (Spondias mombin), passionflower (Passiflora incarnata), chamomile (Matricaria chamomilla),
and muira puama (Ptychopetalum olacoides).
Suggested Use: Take 2-3 capsules twice daily or every 4-6 hours as needed.
Contraindications:
• Not to be used during pregnancy or while breast-feeding.
• Several plants in this formula have been documented to reduce blood pressure in animal studies.
Individuals with low blood pressure should be monitored for this possible effect.
Drug Interactions: May potentiate hypotensive, MAO-inhibitor, sedatives and anxiolytic medications.
Other Practitioner Observations and Possible Precautions:
• Manacá contains naturally occuring salicylate. Those allergic to or sensitive to aspirin and salicylates
should avoid this formula. It also contains coumarins which have a blood thinning effect. Those with a
blood disorder such as hemophilia, should be monitored more closely while taking this formula.
• In some individuals this formula may cause drowsiness. If this interferes with daily work, the dosage
should be reduced.
Synopsis of research: (Please the online Tropical Plant Database for all cited research.).)
• Mulungu has demonstrated in 4 recent rat studies to possess effective anxiolytic actions and in another
study it demonstrated sedative and CNS-depressant actions. In a 2006 study, mulungu was reported to
increase memory and learning. In one of the studies on anxiolytic actions, the researchers reported that
mulungu had an effect similar to the commonly-prescribed anti-anxiety drug diazepam. Brazilian researchers
reported in two 2007 animal studies that the anxiolytic action of mulungu could be atttributed
to two erythravine chemicals found in the plant. In an earlier study, they suggested that these alkaloids
may alter GABAergic neurotransmission. GABA (gamma-amino butyric acid) acts as a neurotransmitter
in the brain; abnormalities with its function is implicated in diseases including epilepsy, anxiety, and
depression.
• Manacá has been reported to act as a central nervous system depressant in animal studies.
• Piri-piri has been reported in animal studies to mediate many of the brain chemical reactions which are
present in epilepsy. Other animal research documents the plant with anti-epileptic, anticonvulsant and
sedative actions.
• Graviola has shown in animal studies to have antidepressant and sedative actions. One study reported
an increase in dopamine, norepinephrine, and monomine oxidase activity, as well as a inhibition of
serotonin release in stress-induced rats.
• Catuaba has demonstrated anti-stress and antidepressant actions in both in vivo and in vitro testing by
inhibiting the uptake and increasing the release of serotonin and dopamine.
• Iporuru has been reported in several animal studies with analgesic, and anti-inflammatory actions.
• Ubos, in lab studies with rats and mice, was reported to be a more potent anxiolytic than diazepam. In
other in vivo tests, ubos has been reported to be anticonvulsant, sedative, and antidopaminergic.
• Passionflower contains naturally occurring serotonin as well as a chemical called maltol which has
documented sedative effects and which might explain the natural calming properties of passionflower.
• For years researchers attributed the sedative effect of chamomile to the flavonoids, but it has recently
been demonstrated through numerous trials that other constituents also contribute substantially to the
total sedative action of chamomile.
• Muira puama has been documented with anxiogenic, memory enhancement, antifatigue, antistress, and
neuroprotective actions in recent animal and human studies.