Organ Specific Guide - Raintree Nutrition, Inc

SIMAROUBA EXTRACT
Description: The main active group of chemicals in simarouba are called quassinoids. The antiprotozoal
and antimalarial properties of these chemicals have been documented for many years. Several of the
quassinoids found in simarouba (such as ailanthinone, glaucarubinone, and holacanthone) are considered
the plant's main therapeutic constituents and are the ones documented to be antiprotozal, anti-amebic,
antimalarial, and even toxic to cancer and leukemia cells. Raintree's simarouba extract uses proprietary
extraction methods which provide the equivalent of 500 mg simarouba bark per milliliter of extract.
Traditional uses by organ or system: Digestion/Elimination: For dysentery and diarrhea, and as a bitter
digestive aid to increase digestive juices and bile.
Ingredients: Pure 100% simarouba bark (Simarouba amara) extracted in distilled water and ethanol.
Suggested Use: Take 60 drops 2-3 times daily or as needed.
Contraindications: None reported
Drug Interactions: None reported.
Other Practitioner Observations and Possible Precautions: Reported side effects at high dosages
(approx. 5 times the suggested use) include increased perspiration and urination, nausea, and/or vomiting.
Synopsis of research: (Please the online Tropical Plant Database for Simarouba for all cited research.)
The leaves and bark of Simarouba have long been used as a natural medicine in the tropics. Simarouba
was first imported into France from Guyana in 1713 as a remedy for dysentery. When France suffered a
dysentery epidemic from 1718 to 1725, simarouba bark was one of the few effective treatments. French
explorers "discovered" this effective remedy when they found that the indigenous Indian tribes in the
Guyana rainforest used simarouba bark as an effective treatment for malaria and dysentery—much as they
still do today. Other indigenous tribes throughout the South American rainforest use simarouba bark for
fevers, malaria, and dysentery, as a hemostatic agent to stop bleeding, and as a tonic.
After a 200-year documented history of use for dysentery, simarouba's use for amebic dysentery was
validated by conventional doctors in 1918. A military hospital in England demonstrated that the bark tea was
an effective treatment for amebic dysentery in humans. The Merck Institute reported that simarouba was
91.8% effective against intestinal amebas in humans in a 1944 study and, in 1962, other researchers found
that simarouba showed active anti-amebic activities in humans. In the 1990s scientists again documented
simarouba's ability to kill the most common dysentery-causing organism, Entamoeba histoly-tica, as well
as two diarrhea-causing bacteria, Salmonella and Shigella.