Organ Specific Guide - Raintree Nutrition, Inc

AMAZON CNS SUPPORT
Description: A synergistic formula of 6 rainforest botanicals traditionally used in South America as
analgesics, to support the central nervous system, and to mediate pain processing pathways.
Traditional uses by organ or system: Brain/CNS: For pain related to the central nervous system,
migraines, nerve injuries, sciatica, and neuropathy.
Ingredients: A proprietary blend of pau d’arco (Tabebuia impetiginosa), tayuya (Cayaponia tayuya),
manacá (Brunfelsia uniflorus), mulungu (Erythrina mulungu), amor seco (Desmodium adscendens), and
iporuru (Alchornea castaneifolia).
Suggested Use: Take 2-3 capsules every 4-6 hours as needed.
Contraindications:
• Not to be used during pregnancy or while breast-feeding.
• Manacá has documented anticoagulant activity. People with blood disorders such as hemophilia, should
be monitored closely for this possible effect.
• May potentiate anticoagulants, MAO-inhibitors and antihypertensive medications.
Other Practitioner Observations and Possible Precautions:
• Manacá contains salicylate. Those with an allergy or sensitivity to salicylates or aspirin may be sensitive
to this formula.
• This formula may cause drowsiness at higher dosages. If this occurs, reduce the amount used.
• Plants in this formula may reduce blood pressure. Those with low blood pressure should be monitored
more closely for this effect.
Synopsis of research: (Please the online Tropical Plant Database for all cited research.).)
• Pau d’arco has demonstrated analgesic, antinociceptive and antiedematogenic actions in animal studies.
An aqueous extract, administered orally to mice, reduced the nociception produced by acetic acid by
63.7%. The aqueous extract (200 and 400 mg/kg, p.o.) reduced formalin effects at the second phase
of the experiment by 49.3% and 53.7%, respectively.
• Novel cucurbitacins have been discovered in tayuya and named cayaponosides (24 distinct cayaponosides
have been discovered thus far). These phytochemicals have been documented to have
antioxidant, anti-inflammatory and analgesic properties. Two animal studies, performed in the early
1990s, verified that tayuya provided analgesic and anti-inflammatory actions. One study documented that
a root infusion given intragastrically to mice had an analgesic action. Another research group prepared
the root in a methanol extract and reported anti-inflammatory actions when administered orally to mice.
• Manacá contains a significant amount of scopoletin, a well known plant chemical with analgesic actions.
In a 1991 clinical study with mice, manacá demonstrated analgesic and anti-inflammatory effects. An
earlier (1977) study reported that manacá evidenced marked anti-inflammatory actions in rats—as well
as central nervous system depressant and antipyretic actions.
• Mulungu is documented with 20 isoquinoline alkaloids, many of which have demonstrated analgesic, antiinflammatory,
cardioactive, narcotic, and sedative activities. The traditional use of mulungu as a nervine
for anxiety and stress has been validated by researchers in a recent (2002) study, where it was shown
to alter anxiety-related responses. The researchers reported that mulungu had an effect similar to the
commonly-prescribed anti-anxiety drug diazepam.
• Amor seco has been documented in animal studies to have analgesic actions as well as anticonvulsant,
anti-inflammatory, antispasmodic, and anti-anaphylactic actions.
• Several animal studies confirm iporuru’s analgesic, anti-inflammatory and COX-inhibition actions. In
Peruvian herbal medicine systems it is a popular herbal remedy for arthritic and rheumatic aches and
pains.