Clinical and Technical Review - Tecomedical

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14 Cartilage - Type II procollagen Figure 3: Schematic drawing of type II procollagen and the localization of the different epitopes. Numbering is based on the amino-acid sequence of an alpha (II) chain of human type IIB collagen (COL2A1_HUMAN, P02458, UniProtKB, Swiss). * Type IIA procollagen would include an additional sequence of sixty-nine amino-acids at position 29-97, the numbering of the following sections would be shifted accordingly
Cartilage Biomarker and their behavior in various arthritis clinical situations Biomarker (u = urinary; s = serum; syn = synovial fluid; c = cellculture)) Clinical situation Degradation marker Formation marker u CTX-II s C2C s C1,2C c C1,2C s COMP 1) Only the ratio of C2C / C1,2C was prognostic. 2) Changes in serum COMP are prognostic, not baseline levels. 3) Prognostic for rapid joint destruction. 4) Levels reflect the degree of synovial inflammation. syn s CPII COMP syn CPII s PIINP s Aggrecan Epitop syn Aggrecan Epitop s YKL-40 OA ↑ ↑ ↑ ↑ ↑ ↓/N ↑ ↓ ↑ ↑ ↑ OA Early ↑ ↑ ↑ N OA Late ↑ ↑ ↑ OA Severity (Baseline levels indicate severity) OA Prognosis (Baseline levels predict progression) syn YKL-40 + + 2) + ± 4) + 5) + 1) + 1) + + 5) RA ↑ ↑ ↑ ↑ ↑ ↑ ↓ ↑ ↑ RA Early ↑ ↑ ↑ RA Late ↑ RA Progressive (Levels in progressive RA resulting in rapid joint destruction) ↑ ↑ ↑ ↑ ↑ ↓/N RA Chronic ↑ ↑ ↑ RA Severity (Baseline levels indicate severity) RA Prognosis (Baseline levels predict progression) + + ± 4) + + + + 3) − + + 5) Patients with knee OA are characterized by an uncoupling of type II collagen synthesis and degradation which can be detected by assays for serum PIINP and urinary CTX-II. The combination of CTX-II and PIINP measurements seems prognostic for identifying knee OA patients at high risk for rapid progression of joint damage. Table was adapted from Schaller et al. (2005). 15
Page 1 and 2: Author: Peter Haima, Ph Clinical an
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Page 7 and 8: Bone Turnover - Biochemical Marker
Page 9 and 10: Bone marker and their behavior in v
Page 11 and 12: Biomarker according to NIH Osteoart
Page 13: Cartilage Synthesis - Biochemical M
Page 17 and 18: Bonemarker normal values for childr
Page 19 and 20: Specific recommendations BAP Osteoc
Page 21 and 22: Bone marker - Reference values in a
Page 23 and 24: Cross reactivity - different specie

Clinical and Technical Review - Tecomedical

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