Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs Pharmacology of Antiepileptic Drugs
Generalized seizures • Absence seizures (Petit mal): sudden onset and abrupt cessation; brief duration, consciousness is altered; attack may be associated with mild clonic jerking of the eyelids or extremities, postural tone changes, autonomic phenomena and automatisms (difficult diagnosis from partial); characteristic 2.5-3.5 Hz spike-and wave pattern • Myoclonic seizures: myoclonic jerking is seen in a wide variety of seizures but when this is the major seizure type it is treated differently to some extent from partial leading to generalized
Generalized Seizures (cont) • Atonic seizures: sudden loss of postural tone; most often in children but may be seen in adults • Tonic-clonic seizures (grand mal): major convulsions with rigidity (tonic) and jerking (clonic), this slows over 60-120 sec followed by stuporous state (post-ictal depression)
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- Page 13 and 14: Antiepileptic Drug A drug which de
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- Page 17 and 18: General Facts About AEDs • Good o
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- Page 21 and 22: Targets for AEDs • Increase inhib
- Page 23 and 24: Epilepsy—Glutamate Epilepsy Gluta
- Page 25 and 26: Felbamate • Antagonizes the glyci
- Page 27 and 28: Epilepsy—GABA Epilepsy GABA Majo
- Page 29 and 30: Clonazapam • -Benzodiazepine used
- Page 31 and 32: Phenobarbital - Barbiturate used fo
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- Page 37 and 38: Carbamazapine • A tricyclic antid
- Page 39 and 40: Zonisamide • Used as add-on thera
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- Page 43 and 44: Gabapentin and its second generatio
- Page 45 and 46: Valproate (Valproic Acid) • First
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Generalized seizures<br />
• Absence seizures (Petit mal): sudden onset and<br />
abrupt cessation; brief duration, consciousness is<br />
altered; attack may be associated with mild clonic<br />
jerking <strong>of</strong> the eyelids or extremities, postural tone<br />
changes, autonomic phenomena and automatisms<br />
(difficult diagnosis from partial); characteristic 2.5-3.5<br />
Hz spike-and wave pattern<br />
• Myoclonic seizures: myoclonic jerking is seen in a<br />
wide variety <strong>of</strong> seizures but when this is the major<br />
seizure type it is treated differently to some extent from<br />
partial leading to generalized
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