Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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Valproate (Valproic Acid)<br />
• First-line for generalized seizures, also used for<br />
partial seizures<br />
• Also blocks Na+ channels and enhances<br />
GABAergic transmission (highly pleiotropic*)<br />
• Highly bound to plasma proteins; #Inhibits P450<br />
• CNS depressant; GI disturbances; hair loss;<br />
weight gain; teratogenic; (rare: hepatotoxic)