Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Lamotrigine<br />
• Add-on therapy, or monotherapy for refractory<br />
partial seizures<br />
• Also inhibits glutamate release and (perhaps)<br />
Ca2+ channels (=pleiotropic*)<br />
• Metabolism affected by Valproate,<br />
Carbamazapine, Phenobarbital, Phenytoin<br />
• Less sedating than other AEDs; (Severe<br />
dermatitis in 1-2% <strong>of</strong> pediatric patients)