Pharmacology of Antiepileptic Drugs

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Phenytoin • First-line for partial seizures; some use for tonicclonic seizures • Highly bound to plasma proteins – displaced by Valproate; #Induces P450 resulting in increase in its own metabolism, but its metabolism is also increased by alcohol, diazepam • Sedating • Fosphenytoin: Prodrug for Phenytoin, used for IM injection
Carbamazapine • A tricyclic antidepressant used for partial seizures; some use in tonic-clonic seizures • #Induces P450 resulting in increase in its own metabolism; • Sedating; Agranulocytosis and Aplastic anemia (elderly); Leukopenia (10% <strong>of</strong> patients); Hyponatremia; Nausea and visual disturbances
Page 1 and 2: Pharmacology of Antiepileptic Drugs
Page 3 and 4: Simple Complex Partial Seizures lo
Page 5 and 6: Complex Partial Seizures Local ons
Page 7 and 8: In generalized seizures, both hemis
Page 9 and 10: Generalized Seizures (cont) • Ato
Page 11 and 12: Video http://www.youtube.com/watch?
Page 13 and 14: Antiepileptic Drug A drug which de
Page 15 and 16: Current Pharmacotherapy • Just un
Page 17 and 18: General Facts About AEDs • Good o
Page 19 and 20: Side effect issues • Sedation - e
Page 21 and 22: Targets for AEDs • Increase inhib
Page 23 and 24: Epilepsy—Glutamate Epilepsy Gluta
Page 25 and 26: Felbamate • Antagonizes the glyci
Page 27 and 28: Epilepsy—GABA Epilepsy GABA Majo
Page 29 and 30: Clonazapam • -Benzodiazepine used
Page 31 and 32: Phenobarbital - Barbiturate used fo
Page 33 and 34: Na+ Channels as AED Targets • Neu
Page 35: AEDs That Act Primarily on Na+ Phen
Page 39 and 40: Zonisamide • Used as add-on thera
Page 41 and 42: Ca 2+ Channels as Targets • Gener
Page 43 and 44: Gabapentin and its second generatio
Page 45 and 46: Valproate (Valproic Acid) • First
Page 47 and 48: Levetiracetam • -Add-on therapy f
Page 49 and 50: Drug Interactions • Many AEDs are
Page 51 and 52: Treatment of Epilepsy • First con
Page 53 and 54: Partial seizures Simple Complex Sec
Page 55 and 56: • Treatment Status Epilepticus -
Page 57: Questions?

Pharmacology of Antiepileptic Drugs

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