Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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Na +<br />
A = activation gate<br />
I = inactivation gate<br />
Anticonvulsants:<br />
Mechanisms <strong>of</strong> Action<br />
Voltage-gated sodium channel<br />
I<br />
Open Inactivated<br />
Carbamazepine<br />
Phenytoin<br />
McNamara JO. Goodman & Gilman’s. 9th ed. 1996:461-486.<br />
Na +<br />
X<br />
Na + Na +<br />
I<br />
Lamotrigine<br />
Valproate