Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs
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Glutamate Receptors as AED Targets<br />
• NMDA receptor sites as targets<br />
– Ketamine, phencyclidine, dizocilpine block channel<br />
and have anticonvulsant properties but also<br />
dissociative and/or hallucinogenic properties; open<br />
channel blockers.<br />
• AMPA receptor sites as targets<br />
– Since it is the “workhorse” receptor can anticipate<br />
major sedative effects
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