Pharmacology of Antiepileptic Drugs
Pharmacology of Antiepileptic Drugs Pharmacology of Antiepileptic Drugs
Cellular Mechanisms of Seizure Generation emedicine.com
Targets for AEDs • Increase inhibitory neurotransmitter system— GABA • Decrease excitatory neurotransmitter system— glutamate • Block voltage-gated inward positive currents— Na + or Ca ++ • Increase outward positive current—K + • Many AEDs pleiotropic—act via multiple mechanisms
- Page 1 and 2: Pharmacology of Antiepileptic Drugs
- Page 3 and 4: Simple Complex Partial Seizures lo
- Page 5 and 6: Complex Partial Seizures Local ons
- Page 7 and 8: In generalized seizures, both hemis
- Page 9 and 10: Generalized Seizures (cont) • Ato
- Page 11 and 12: Video http://www.youtube.com/watch?
- Page 13 and 14: Antiepileptic Drug A drug which de
- Page 15 and 16: Current Pharmacotherapy • Just un
- Page 17 and 18: General Facts About AEDs • Good o
- Page 19: Side effect issues • Sedation - e
- Page 23 and 24: Epilepsy—Glutamate Epilepsy Gluta
- Page 25 and 26: Felbamate • Antagonizes the glyci
- Page 27 and 28: Epilepsy—GABA Epilepsy GABA Majo
- Page 29 and 30: Clonazapam • -Benzodiazepine used
- Page 31 and 32: Phenobarbital - Barbiturate used fo
- Page 33 and 34: Na+ Channels as AED Targets • Neu
- Page 35 and 36: AEDs That Act Primarily on Na+ Phen
- Page 37 and 38: Carbamazapine • A tricyclic antid
- Page 39 and 40: Zonisamide • Used as add-on thera
- Page 41 and 42: Ca 2+ Channels as Targets • Gener
- Page 43 and 44: Gabapentin and its second generatio
- Page 45 and 46: Valproate (Valproic Acid) • First
- Page 47 and 48: Levetiracetam • -Add-on therapy f
- Page 49 and 50: Drug Interactions • Many AEDs are
- Page 51 and 52: Treatment of Epilepsy • First con
- Page 53 and 54: Partial seizures Simple Complex Sec
- Page 55 and 56: • Treatment Status Epilepticus -
- Page 57: Questions?
Targets for AEDs<br />
• Increase inhibitory neurotransmitter system—<br />
GABA<br />
• Decrease excitatory neurotransmitter system—<br />
glutamate<br />
• Block voltage-gated inward positive currents—<br />
Na + or Ca ++<br />
• Increase outward positive current—K +<br />
• Many AEDs pleiotropic—act via multiple<br />
mechanisms
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