GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
10.1.C C20-24 Alpha Olefins, Branched and Linear, • Fish Acute Toxicity Test (Safepharm Laboratories Limited 1998) • Alga Growth Inhibition Test (Safepharm Laboratories Limited 1998) • Acute Immobilisation Test (Safepharm Laboratories Limited 1998) The definitive tests on all three species were performed using media made up with WAFs prepared at nominal loading of 1 000 mg/L of the test substance. The methodologies employed were in accordance with OECD TG 301, 302 and 303 essentially as described above. The daphnia test was conducted with four replicates (5 animals per test vessel) and the alga test was conducted with six replicates. In all cases the NOEL was greater than the 1 000 mg/L WAF loading, indicating this fraction as non toxic up to the limit of its water solubility. Activated Sludge Respiration Inhibition Test (Safepharm Laboratories Limited 1998) Using OECD TG 209, the study found that the test substance has no effect on aerobic bacterial metabolism after 3 hours exposure to media containing WAF prepared at 1 000 mg/L loading. Although the use pattern of Gulftene 16-18 is such that entry into the sewer system is unlikely, the results of this study are included for completeness. Similarly, in the various tests for aerobic biodegradation, the reports indicated no observable inhibition of bacterial respiration. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 80 of 100
10.2 TESTS ON MARINE ORGANISMS Exotic Species Test reports and summary reports on the toxicity of C16-18 olefins isomerised, C14-20 olefins isomerised and drilling muds containing these materials to a variety of Northern Hemisphere marine organisms were submitted and are summarised in the table below. Test Species Results (WAF - Nominal) Acute Toxicity to Fish Acute Toxicity to Marine Shrimp Acute Toxicity to Marine Shrimp Acute Toxicity to Marine Copepod Acute Toxicity to Marine Copepod Acute Toxicity to Marine Amphipod Acute Toxicity to Marine Amphipod Inhibition of Marine Algal Growth Inhibition of Marine Algal Growth Scopthalmus maximus (turbot) Mysidopsis bahia (mysid shrimp) Mysidopsis bahia (mysid shrimp) * LL50(96 h) > 10 000 mg/L NOEC (96 h) > 10 000 mg/L LL50(96 h) > 195 g/L See notes below LL50(96 h) > 53.8 g/L See notes below Acartia tonsa LL50(48 h) > 10 000 mg/L See notes below Acartia tonsa LL50(48 h) > 10 000 mg/L See notes below Corophium volutator LL50(10 day) = 1 250 mg/kg See notes below Corophium volutator LL50(10 day) = 1 560 mg/kg See notes below Skeletonema costatum EbL50(72 h) > 5 600 mg/L **NOEL(72 h) = 1 800 mg/L Skeletonema costatum EbL50(72 h) > 10 00 mg/L **NOEL(72 h) = 3 200 mg/L *LL50 refers to the nominal loading of test substance used to prepare the WAF media in which 50% of the test animals died at the end of the test period. **NOEL refers to the WAF loading below which no toxic effects are observed. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 81 of 100
- Page 29 and 30: 9.1.1.7 Acute Oral Toxicity of Othe
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- Page 43 and 44: Mean group score (24, 48 & 72 hour
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- Page 51 and 52: Draize scores of non irrigated eyes
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- Page 59 and 60: that sensitisation may have been in
- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
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- Page 67 and 68: were observed at the end of the rec
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- Page 79: with 42% less growth (relative to t
- Page 83 and 84: 6.25% WAF 5 of the test animals had
- Page 85 and 86: NOEL (96 h) < 0.09 g/L FULL PUBLIC
- Page 87 and 88: the 48 hour NOEL was less than 1 90
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- Page 91 and 92: R65 - May Cause Lung Damage if Swal
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- Page 95 and 96: Gerarde, H. (1963) Toxicological St
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- Page 99 and 100: Wildlife International Ltd (1995) 1
10.2 TESTS ON MARINE ORGANISMS<br />
Exotic Species<br />
Test reports and summary reports on the toxicity of <strong>C16</strong>-<strong>18</strong> olefins isomerised, C14-20<br />
olefins isomerised and drilling muds containing these materials to a variety of Northern<br />
Hemisphere marine organisms were submitted and are summarised in the table below.<br />
Test Species Results (WAF - Nominal)<br />
Acute Toxicity to Fish<br />
Acute Toxicity to Marine<br />
Shrimp<br />
Acute Toxicity to Marine<br />
Shrimp<br />
Acute Toxicity to Marine<br />
Copepod<br />
Acute Toxicity to Marine<br />
Copepod<br />
Acute Toxicity to Marine<br />
Amphipod<br />
Acute Toxicity to Marine<br />
Amphipod<br />
Inhibition of Marine<br />
Algal Growth<br />
Inhibition of Marine<br />
Algal Growth<br />
Scopthalmus maximus<br />
(turbot)<br />
Mysidopsis bahia<br />
(mysid shrimp)<br />
Mysidopsis bahia<br />
(mysid shrimp)<br />
* LL50(96 h) > 10 000 mg/L<br />
NOEC (96 h) > 10 000 mg/L<br />
LL50(96 h) > 195 g/L<br />
See notes below<br />
LL50(96 h) > 53.8 g/L<br />
See notes below<br />
Acartia tonsa LL50(48 h) > 10 000 mg/L<br />
See notes below<br />
Acartia tonsa LL50(48 h) > 10 000 mg/L<br />
See notes below<br />
Corophium volutator LL50(10 day) = 1 250 mg/kg<br />
See notes below<br />
Corophium volutator LL50(10 day) = 1 560 mg/kg<br />
See notes below<br />
Skeletonema costatum EbL50(72 h) > 5 600 mg/L<br />
**NOEL(72 h) = 1 800 mg/L<br />
Skeletonema costatum EbL50(72 h) > 10 00 mg/L<br />
**NOEL(72 h) = 3 200 mg/L<br />
*LL50 refers to the nominal loading of test substance used to prepare the WAF media in which 50% of the test<br />
animals died at the end of the test period.<br />
**NOEL refers to the WAF loading below which no toxic effects are observed.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 81 of 100
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