GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
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9.3.1.6 In Vitro Genotoxicity of 1-octadecene (EU 1995)<br />
The following data are taken from the HEDSET data sheet for 1-octadecene. The full study<br />
reports were not provided in the submission.<br />
The HEDSET documents indicate these tests were not conducted in accordance with GLP or<br />
OECD or EC testing guidelines.<br />
1-Octadecene was considered not mutagenic or clastogenic in the following test systems:<br />
Test Comment Result<br />
Bacterial Reverse<br />
Mutation Assay H<strong>18</strong><br />
Mitotic<br />
Recombination H<strong>18</strong><br />
Chromosome<br />
Aberration H<strong>18</strong><br />
9.3.2 In Vivo<br />
S. typhimurium TA98, TA 100, TA 1535,<br />
TA 1537, TA 1538. E. coli WP2, WP2uvrA.<br />
0.2 to 2 000 µg/plate;<br />
with and without metabolic activation.<br />
S.cerevisiae JD1.<br />
0.01 to 5.0 mg/mL;<br />
with and without metabolic activation.<br />
Rat liver RL1 cells.<br />
0 to 500 µg/mL as acetone solution.<br />
With and without metabolic activation.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 72 of 100<br />
Negative<br />
Negative<br />
Negative<br />
9.3.2.1 Mammalian Erythrocyte Micronucleus Test Using Gulftene 12-16 (Gulf<br />
Life Sciences Center 1983)<br />
Test substance: Gulftene 12-16<br />
Species/strain: Mouse/Crl:CD-1 (ICR) BR<br />
Number and sex of animals: 5/sex/group<br />
Doses/Method of<br />
administration:<br />
Test substance: 1 000, 2 500 or 5 000 mg/kg;<br />
Vehicle control: corn oil;<br />
Test and vehicle control administered dermally to shaven<br />
backs of mice once per day for 2 days;<br />
Positive control, cyclophosphamide 75 mg/kg,<br />
administered via intraperitoneal injection;<br />
Sampling schedule: Test and vehicle control animals were sacrificed 24 or 48<br />
hours after last dosing;