GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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Dosing schedule: Each concentration was tested in duplicate with or without metabolic activation (S9), in two independent experiments Test method: OECD TG 473 Experiment 1 (repeat – see comment below): without S9, 0*, 78.13, 156.25, 312.5*, 625*, 1 250* ,2 500* 5 000* µg/mL; treatment/harvest time = 4/20 hours; positive control: ethyl methanesulphonate 750µg/mL; with S9, 0*, 39.06, 78.13, 156.25, 312.5*, 625*, 1 250*, 2 500* 5 000* µg/mL, treatment/harvest time = 4/20 hours, positive control: cyclophosphamide 25µg/mL; Experiment 2: without S9, 0*, 39.06, 78.13, 156.25, 312.5*, 625* 1 250*, 2 500* 5 000* µg/mL; treatment/harvest time = 20/20 hours; positive control: ethyl methanesulphonate 500µg/mL; with S9 (increased to a final concentration of 2%), 0*, 39.06 , 78.13, 156.25, 312.5*, 625* 1 250*, 2 500* 5 000* µg/mL; treatment/harvest time: 4/20 hours, positive control: cyclophosphamide 25 µg/mL; asterisk* indicates cultures selected for metaphase analysis Comment: An initial experiment (data not included in report) revealed: doses of 2 500 and 5 000 g/mL were probably beyond the maximum practical dose; an aberrant cell at the highest dose contained multiple aberrations; and weak responses in the positive control. The experiment was repeated. In the repeated Experiment 1 and Experiment 2, an oily layer was observed at and above 156.25 µg/mL and 312.5µg/mL in the presence and absence of metabolic activation, respectively. No toxicity was observed at any concentration. The test substance did not cause any significant increases in the incidence of cells with chromosomal aberrations, polyploidy or endoreplication, at the concentrations analysed in the presence or absence of metabolic activation. Positive controls used in the test caused significant FULL PUBLIC REPORT 26 April 2000 NA/713 Page 70 of 100
increases in the incidence of aberrant cells and the activity of the S9 fraction was found to be satisfactory. Result: C20-C24 alkenes, branched and linear was not considered to be clastogenic under the conditions of this chromosomal aberration test. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 71 of 100
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File No: NA/713 26 April 2000 NATIO
Page 3 and 4:
3. PHYSICAL AND CHEMICAL PROPERTIES
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Hydrolysis as a Function of pH: Dis
Page 7 and 8:
No definitive test results for the
Page 9 and 10:
18 and are automatically discharged
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esultant oil/water emulsion is pass
Page 13 and 14:
The results for a modified Sturm te
Page 15 and 16:
was also performed according to the
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9. EVALUATION OF TOXICOLOGICAL DATA
Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
Page 23 and 24: 9.3.1.5 Chromosome aberration Human
Page 25 and 26: Clinical observations: A few days a
Page 27 and 28: LD50: > 5 000 mg/kg Result: C20-24
Page 29 and 30: 9.1.1.7 Acute Oral Toxicity of Othe
Page 31 and 32: hair at the treatment site. Morphol
Page 33 and 34: Result: C20-24 Alkenes, branched an
Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
Page 39 and 40: Draize score abraded skins: Time af
Page 41 and 42: 9.1.5.3 Acute Dermal Irritation of
Page 43 and 44: Mean group score (24, 48 & 72 hour
Page 47 and 48: Draize scores: Time after Animal #
Page 51 and 52: Draize scores of non irrigated eyes
Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
Page 55 and 56: Draize scores of irrigated eyes: Ti
Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
Page 59 and 60: that sensitisation may have been in
Page 61 and 62: Number of animals: 20 test animals,
Page 63 and 64: liver parenchyma. Result: Repeated
Page 65 and 66: Pathology: F0 males and satellite f
Page 67 and 68: were observed at the end of the rec
Page 69: negative control. The positive cont
Page 73 and 74: Clinical observations: No mortality
Page 75 and 76: hour observation and crust formatio
Page 77 and 78: 10. ASSESSMENT OF ENVIRONMENTAL EFF
Page 79 and 80: with 42% less growth (relative to t
Page 81 and 82: 10.2 TESTS ON MARINE ORGANISMS Exot
Page 83 and 84: 6.25% WAF 5 of the test animals had
Page 85 and 86: NOEL (96 h) < 0.09 g/L FULL PUBLIC
Page 87 and 88: the 48 hour NOEL was less than 1 90
Page 89 and 90: 11. ASSESSMENT OF ENVIRONMENTAL HAZ
Page 91 and 92: R65 - May Cause Lung Damage if Swal
Page 93 and 94: 14. MATERIAL SAFETY DATA SHEET The
Page 95 and 96: Gerarde, H. (1963) Toxicological St
Page 97 and 98: Safepharm Laboratories Limited (199
Page 99 and 100: Wildlife International Ltd (1995) 1
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GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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