GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
treatment free period of 4 weeks for high dose and control<br />
animals<br />
Number/sex of animals: 10/sex/treatment and control groups;<br />
10/sex/recovery groups (control and 1 000 mg/kg/day)<br />
Test method: OECD TG 408<br />
Mortality: Nil<br />
Clinical observations:<br />
No treatment related signs were observed on clinical signs, bodyweight, opthalmoscopy or<br />
neurobehaviour.<br />
Clinical chemistry/Haematology<br />
Clinical chemistry:<br />
Significantly increased glucose levels at Week 13 in 500 and 1 000 mg/kg/day males.<br />
Glucose levels were normal in males of 1 000 mg/kg/day group at the end of the recovery<br />
period.<br />
Haematology:<br />
Decreased erythrocyte indices (packed cell volume of males and females, haemoglobin<br />
values of males and erythrocyte count of females) and prolonged haemostatic indices<br />
(males) in animals of the 1 000 mg/kg/day groups at Week 13. All indices were normal<br />
after the recovery period. Significantly increased platelet counts persisted in males of the<br />
1 000 mg/kg/day at the end of the recovery period.<br />
Pathology:<br />
Organ weights:<br />
Females at all treatment doses had significantly higher group mean liver weight. No dosage<br />
response was apparent. Males receiving 1 000 mg/kg/day had slightly increased mean body<br />
weight-adjusted liver weight. These changes were not apparent at the end of the recovery<br />
period. Significantly higher group mean absolute adrenal weights in females receiving 500<br />
and 1 000 mg/kg/day. These changes were not apparent at the end of the recovery period.<br />
Macroscopic:<br />
No treatment related effects.<br />
Microscopic:<br />
Minimal centrilobular hepatocyte hypertrophy was observed in a small number of females<br />
of all treated groups, the incidence attaining statistical significance at the 1 000 mg/kg/day<br />
group. Significantly increased incidence of adrenal cortical hypertrophy in females of the<br />
1 000 mg/kg/day group. Significantly increased incidence of epithelial hyperplasia of the<br />
limiting ridge 4 of the stomach in males receiving 1 000 mg/kg/day. None of these lesions<br />
4 This is considered to reflect local irritation of the test material in corn oil and since humans do not have a<br />
limiting ridge this effect is considered to be of no toxicological significance.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 66 of 100