GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Day 7 - filter paper saturated with the test substance as<br />
supplied was applied to the treated area and held under<br />
occlusive dressing for 48 hours;<br />
Control animals:<br />
treated similarly to the test animals omitting the test<br />
substance from the intradermal injections and topical<br />
application<br />
Challenge procedure: Test and Control Animals:<br />
Day 21: filter paper saturated with 75% v/v and 50% v/v of<br />
test substance in arachis oil, was applied to two sites on the<br />
left flank, and held under occlusive dressing for 24 hours;<br />
Challenge Outcome: Challenge concentration of 75%: no dermal reactions were<br />
noted in test or control animals;<br />
Challenge concentration of 50%: no dermal reactions were<br />
noted in test or control animals.<br />
Result: C20-24 Alkenes, branched and linear was non sensitising to<br />
guineapig skin.<br />
9.1.7.4 Skin Sensitisation of Other Alkenes<br />
9.1.7.4.1 Skin Sensitisation of Other Alkenes - Neodene 16 alpha olefin (Morris<br />
TD, 1992 cited in HEDSET, 1-hexadecene)<br />
Test substance: Neodene 16 alpha olefin (1-hexadecene)<br />
Species/strain: Guineapig/strain not specified<br />
Number of animals: 20 test animals, 10 control animals, sex not specified<br />
Test method: Buehler technique<br />
Induction/Challenge<br />
Procedure:<br />
No details provided.<br />
Challenge Outcome: No details of dermal reactions provided.<br />
Result: Neodene 16 alpha olefin was reported non sensitising to<br />
guineapig skin.<br />
9.1.7.4.2 Skin Sensitisation of Other Alkenes - Neodene <strong>18</strong> alpha olefin (Morris<br />
TD, 1992 cited in HEDSET (1-octadecene)<br />
Test substance: Neodene <strong>18</strong> alpha olefin (1-octadecene)<br />
Species/strain: Guineapig/strain not specified<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 60 of 100