GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

Day 7 - filter paper saturated with the test substance as
supplied was applied to the treated area and held under
occlusive dressing for 48 hours;
Control animals:
treated similarly to the test animals omitting the test
substance from the intradermal injections and topical
application
Challenge procedure: Test and Control Animals:
Day 21: filter paper saturated with 75% v/v and 50% v/v of
test substance in arachis oil, was applied to two sites on the
left flank, and held under occlusive dressing for 24 hours;
Challenge Outcome: Challenge concentration of 75%: no dermal reactions were
noted in test or control animals;
Challenge concentration of 50%: no dermal reactions were
noted in test or control animals.
Result: C20-24 Alkenes, branched and linear was non sensitising to
guineapig skin.
9.1.7.4 Skin Sensitisation of Other Alkenes
9.1.7.4.1 Skin Sensitisation of Other Alkenes - Neodene 16 alpha olefin (Morris
TD, 1992 cited in HEDSET, 1-hexadecene)
Test substance: Neodene 16 alpha olefin (1-hexadecene)
Species/strain: Guineapig/strain not specified
Number of animals: 20 test animals, 10 control animals, sex not specified
Test method: Buehler technique
Induction/Challenge
Procedure:
No details provided.
Challenge Outcome: No details of dermal reactions provided.
Result: Neodene 16 alpha olefin was reported non sensitising to
guineapig skin.
9.1.7.4.2 Skin Sensitisation of Other Alkenes - Neodene 18 alpha olefin (Morris
TD, 1992 cited in HEDSET (1-octadecene)
Test substance: Neodene 18 alpha olefin (1-octadecene)
Species/strain: Guineapig/strain not specified
FULL PUBLIC REPORT 26 April 2000
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