GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
9.1.6.5 Acute Eye Irritation of Other Alkenes The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1dodecene 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate these tests were not conducted in accordance with GLP or OECD or EC testing guidelines. In each case the following test substances were instilled into the eyes of New Zealand white rabbits, without eye irrigation. The HEDSET documents reported each of the test substances as non-irritating. Test Substance Mean group score (24, 48 & 72 hour observation) Corneal Iridial Conjunctival Conjunctival opacity inflammation redness chemosis C12 – C14 H14 0.0 0.0 Draize Score = 3.0** C12 - C26* Olefin/Paraffin H18 0.0 0.0 0.2 0.06 C14 – C16 H14 0.0 0.0 Draize Score = 2.1** C14 – C18* Olefin H14 0.0 0.0 Draize Score = 2.7** C14 – C18* Olefin/Paraffin H18 0.0 0.0 0.22 0.4 C14 – C26* Olefin H14 0.0 0.0 Draize Score = 2.7** C14 – C26* Olefin/Paraffin H18 0.0 0.0 0.1 0.3 C18 – C24* Olefins H18 0.0 0.0 0.5 0.6 C18 – C26* Olefin/Paraffin H18 0.0 0.0 0.2 0.3 C18 – C30* Olefin/Alcohol H18 0.0 0.0 0.5 0.6 *Purity not specified. ** Individual scores not given. H14 (EU 1995) H16 (EU 1995) H18 (EU 1995) FULL PUBLIC REPORT 26 April 2000 NA/713 Page 56 of 100
9.1.7 Skin Sensitisation 9.1.7.1 Skin Sensitisation of C12-C16 Alpha Olefins (Rinehart 1967) Test substance: C12 – C16 alpha olefin (98.5% olefins, 1.5% saturates) Species/strain: Guineapig/albino Number of animals: 10 males/group Test method: Landsteiner technique cited in (Rinehart 1967), 1967 #29]) Induction procedure: Test sites on the backs of animals were clipped and scored with a needle. 0.1mL of test substance was applied by glass rod to the test site three times weekly for nine applications. Positive control: 0.5% chlorodinitrobenzene in 50% ethyl alcohol; Vehicle control: 50% ethyl alcohol. Challenge procedure: Following a 2 week rest period after the last induction application 0.1 mL of test article was applied to the skin Challenge Outcome: No dermal response with test substance. The positive control, chlorodinitrobenzene responded appropriately. Result: C12 – C16 alpha olefins was non sensitising to guineapig skin. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 57 of 100
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9.1.7 Skin Sensitisation<br />
9.1.7.1 Skin Sensitisation of C12-<strong>C16</strong> Alpha Olefins (Rinehart 1967)<br />
Test substance: C12 – <strong>C16</strong> alpha olefin (98.5% olefins, 1.5% saturates)<br />
Species/strain: Guineapig/albino<br />
Number of animals: 10 males/group<br />
Test method: Landsteiner technique cited in (Rinehart 1967), 1967 #29])<br />
Induction procedure: Test sites on the backs of animals were clipped and scored<br />
with a needle. 0.1mL of test substance was applied by glass<br />
rod to the test site three times weekly for nine applications.<br />
Positive control: 0.5% chlorodinitrobenzene in 50% ethyl<br />
alcohol;<br />
Vehicle control: 50% ethyl alcohol.<br />
Challenge procedure: Following a 2 week rest period after the last induction<br />
application 0.1 mL of test article was applied to the skin<br />
Challenge Outcome: No dermal response with test substance.<br />
The positive control, chlorodinitrobenzene responded<br />
appropriately.<br />
Result: C12 – <strong>C16</strong> alpha olefins was non sensitising to guineapig<br />
skin.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 57 of 100
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