GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
9.1.6.4 Acute Eye Irritation of C20-24 Alkenes, branched and linear (Safepharm<br />
Laboratories Limited 1998)<br />
Test Substance: C20-24 Alkenes, branched and linear<br />
Species/strain: Rabbit/New Zealand White<br />
Number/sex of animals: 5 female 4 males<br />
Observation period: 1, 24, 48 and 72 hours post instillation<br />
Method of administration,<br />
Unirrigated eyes:<br />
Method of administration,<br />
Irrigated eyes:<br />
Test method: OECD TG 405<br />
Draize scores of non-irrigated eyes:<br />
A single instillation of 0.1 mL of test substance into the<br />
conjunctival sac of the right eye of 6 rabbits; The left eye<br />
served as the control.<br />
A single instillation of 0.1 mL of test substance into the<br />
conjunctival sac of the right eye of 3 rabbits, after 30<br />
seconds the eye was gently irrigated with 100mL of<br />
lukewarm water for one minute; The left eye served as the<br />
control.<br />
Time after instillation<br />
Animal 1 hour 24 hours 48 hours 72 hours<br />
Conjunctiva r c d r c d r c d r c d<br />
1 0 0 0 0 0 0 0 0 0 0 0 0<br />
2F 1 0 0 0 0 0 0 0 0 0 0 0<br />
3 0 0 0 0 0 0 0 0 0 0 0 0<br />
4F 1 0 0 0 0 0 0 0 0 0 0 0<br />
5 0 0 0 0 0 0 0 0 0 0 0 0<br />
6F 1 0 0 0 0 0 0 0 0 0 0 0<br />
Cornea All individual scores were zero<br />
Iris All individual scores were zero<br />
1 see Attachment 1 for Draize scales<br />
r = redness c = chemosis d = discharge. F = female.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 54 of 100
Change language